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High-throughput Evaluation of Epilepsy-associated KCNQ2 Variants Reveals Functional and Pharmacological Heterogeneity
Carlos G. Vanoye, Reshma R. Desai, Zhigang Ji, Sneha Adusumilli, Nirvani Jairam, Nora Ghabra, Nishtha Joshi, Eryn Fitch, Katherine Helbig, Dianalee McKnight, Amanda Lindy, Fanggeng Zou, Ingo Helbig, Edward Cooper, View ORCID ProfileAlfred L. George Jr.
doi: https://doi.org/10.1101/2021.10.18.464842
Carlos G. Vanoye
1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL USA
Reshma R. Desai
1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL USA
Zhigang Ji
2Departments of Neurology, Neuroscience, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX USA
Sneha Adusumilli
1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL USA
Nirvani Jairam
1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL USA
Nora Ghabra
1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL USA
Nishtha Joshi
2Departments of Neurology, Neuroscience, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX USA
Eryn Fitch
3Children’s Hospital of Philadelphia, Philadelphia, PA USA
Katherine Helbig
3Children’s Hospital of Philadelphia, Philadelphia, PA USA
Dianalee McKnight
4GeneDx, Inc., Gaithersburg, MD, USA
Amanda Lindy
4GeneDx, Inc., Gaithersburg, MD, USA
Fanggeng Zou
4GeneDx, Inc., Gaithersburg, MD, USA
Ingo Helbig
3Children’s Hospital of Philadelphia, Philadelphia, PA USA
Edward Cooper
2Departments of Neurology, Neuroscience, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX USA
Alfred L. George Jr.
1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL USA
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Posted October 19, 2021.
High-throughput Evaluation of Epilepsy-associated KCNQ2 Variants Reveals Functional and Pharmacological Heterogeneity
Carlos G. Vanoye, Reshma R. Desai, Zhigang Ji, Sneha Adusumilli, Nirvani Jairam, Nora Ghabra, Nishtha Joshi, Eryn Fitch, Katherine Helbig, Dianalee McKnight, Amanda Lindy, Fanggeng Zou, Ingo Helbig, Edward Cooper, Alfred L. George Jr.
bioRxiv 2021.10.18.464842; doi: https://doi.org/10.1101/2021.10.18.464842
High-throughput Evaluation of Epilepsy-associated KCNQ2 Variants Reveals Functional and Pharmacological Heterogeneity
Carlos G. Vanoye, Reshma R. Desai, Zhigang Ji, Sneha Adusumilli, Nirvani Jairam, Nora Ghabra, Nishtha Joshi, Eryn Fitch, Katherine Helbig, Dianalee McKnight, Amanda Lindy, Fanggeng Zou, Ingo Helbig, Edward Cooper, Alfred L. George Jr.
bioRxiv 2021.10.18.464842; doi: https://doi.org/10.1101/2021.10.18.464842
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