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Chikungunya virus vaccine candidate incorporating synergistic mutations is attenuated and protects against virulent virus challenge
Anthony J. Lentscher, Nicole McAllister, Kira A. Griswold, James L. Martin, Olivia L. Welsh, Danica M. Sutherland, Laurie A. Silva, Terence S. Dermody
doi: https://doi.org/10.1101/2021.10.19.464869
Anthony J. Lentscher
1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
2Institute for Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
Nicole McAllister
3Department of Biology, Seton Hill University, Pittsburgh, Pennsylvania, USA
Kira A. Griswold
1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
2Institute for Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
James L. Martin
2Institute for Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
4Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Olivia L. Welsh
2Institute for Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
4Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Danica M. Sutherland
2Institute for Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
4Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Laurie A. Silva
2Institute for Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
4Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Terence S. Dermody
1Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
2Institute for Infection, Inflammation, and Immunity, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
4Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

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Posted October 19, 2021.
Chikungunya virus vaccine candidate incorporating synergistic mutations is attenuated and protects against virulent virus challenge
Anthony J. Lentscher, Nicole McAllister, Kira A. Griswold, James L. Martin, Olivia L. Welsh, Danica M. Sutherland, Laurie A. Silva, Terence S. Dermody
bioRxiv 2021.10.19.464869; doi: https://doi.org/10.1101/2021.10.19.464869
Chikungunya virus vaccine candidate incorporating synergistic mutations is attenuated and protects against virulent virus challenge
Anthony J. Lentscher, Nicole McAllister, Kira A. Griswold, James L. Martin, Olivia L. Welsh, Danica M. Sutherland, Laurie A. Silva, Terence S. Dermody
bioRxiv 2021.10.19.464869; doi: https://doi.org/10.1101/2021.10.19.464869
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