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Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line
Daniela Niemeyer, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Anja Richter, Saskia Stenzel, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M. Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Julian Heinze, Felix Walper, Marie L. Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Talitha Veith, Morris Baumgardt, Karen Hoffmann, View ORCID ProfileMarek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, View ORCID ProfileMarkus Morkel, Sandra Ciesek, Leif G. Hanitsch, Marcus A. Mall, Andreas C. Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, View ORCID ProfileVictor M. Corman, View ORCID ProfileMarcel A. Müller, View ORCID ProfileChristine Goffinet, Christian Drosten
doi: https://doi.org/10.1101/2021.10.20.465121
Daniela Niemeyer
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
2German Centre for Infection Research, associated partner Charité, Berlin, Germany
Simon Schroeder
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Kirstin Friedmann
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Friderike Weege
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Jakob Trimpert
3Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, Germany
Anja Richter
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Saskia Stenzel
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
4Berlin Institute of Health, 10178 Berlin, Germany
Jenny Jansen
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
4Berlin Institute of Health, 10178 Berlin, Germany
Jackson Emanuel
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Julia Kazmierski
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
4Berlin Institute of Health, 10178 Berlin, Germany
Fabian Pott
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
4Berlin Institute of Health, 10178 Berlin, Germany
Lara M. Jeworowski
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Ruth Olmer
5Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH - Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany
Mark-Christian Jaboreck
5Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH - Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany
Beate Tenner
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Jan Papies
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Julian Heinze
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
2German Centre for Infection Research, associated partner Charité, Berlin, Germany
Felix Walper
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Marie L. Schmidt
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Nicolas Heinemann
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Elisabeth Möncke-Buchner
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
Talitha Veith
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
2German Centre for Infection Research, associated partner Charité, Berlin, Germany
Morris Baumgardt
6Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany
Karen Hoffmann
6Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany
Marek Widera
7Institute for Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
Tran Thi Nhu Thao
8Institute of Virology and Immunology, Bern, Switzerland
Anita Balázs
9Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany
Jessica Schulze
10Unit 17 “Influenza and other Respiratory Viruses”, Robert Koch Institute, Seestr. 10, 13353 Berlin, Germany
Christin Mache
10Unit 17 “Influenza and other Respiratory Viruses”, Robert Koch Institute, Seestr. 10, 13353 Berlin, Germany
Markus Morkel
11Institute of Pathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
12BIH Bioportal Single Cells, Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany
Sandra Ciesek
7Institute for Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany
17German Center for Infection Research, DZIF, 38124 Braunschweig, Germany
18Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany
Leif G. Hanitsch
13Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Augustenburger Platz 1, Berlin, Germany
Marcus A. Mall
4Berlin Institute of Health, 10178 Berlin, Germany
9Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany
15German Centre for Lung Research (DZL), associated partner Charité, Berlin, Germany
Andreas C. Hocke
6Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany
Volker Thiel
8Institute of Virology and Immunology, Bern, Switzerland
Klaus Osterrieder
3Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, Germany
16Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong
Thorsten Wolff
10Unit 17 “Influenza and other Respiratory Viruses”, Robert Koch Institute, Seestr. 10, 13353 Berlin, Germany
Ulrich Martin
5Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH - Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover Medical School, 30625 Hannover, Germany
Victor M. Corman
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
2German Centre for Infection Research, associated partner Charité, Berlin, Germany
14Labor Berlin – Charité Vivantes GmbH, Berlin, Germany
Marcel A. Müller
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
2German Centre for Infection Research, associated partner Charité, Berlin, Germany
Christine Goffinet
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
4Berlin Institute of Health, 10178 Berlin, Germany
Christian Drosten
1Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
2German Centre for Infection Research, associated partner Charité, Berlin, Germany
4Berlin Institute of Health, 10178 Berlin, Germany
14Labor Berlin – Charité Vivantes GmbH, Berlin, Germany
Article usage
Posted October 20, 2021.
Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line
Daniela Niemeyer, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Anja Richter, Saskia Stenzel, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M. Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Julian Heinze, Felix Walper, Marie L. Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Talitha Veith, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Markus Morkel, Sandra Ciesek, Leif G. Hanitsch, Marcus A. Mall, Andreas C. Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M. Corman, Marcel A. Müller, Christine Goffinet, Christian Drosten
bioRxiv 2021.10.20.465121; doi: https://doi.org/10.1101/2021.10.20.465121
Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line
Daniela Niemeyer, Simon Schroeder, Kirstin Friedmann, Friderike Weege, Jakob Trimpert, Anja Richter, Saskia Stenzel, Jenny Jansen, Jackson Emanuel, Julia Kazmierski, Fabian Pott, Lara M. Jeworowski, Ruth Olmer, Mark-Christian Jaboreck, Beate Tenner, Jan Papies, Julian Heinze, Felix Walper, Marie L. Schmidt, Nicolas Heinemann, Elisabeth Möncke-Buchner, Talitha Veith, Morris Baumgardt, Karen Hoffmann, Marek Widera, Tran Thi Nhu Thao, Anita Balázs, Jessica Schulze, Christin Mache, Markus Morkel, Sandra Ciesek, Leif G. Hanitsch, Marcus A. Mall, Andreas C. Hocke, Volker Thiel, Klaus Osterrieder, Thorsten Wolff, Ulrich Martin, Victor M. Corman, Marcel A. Müller, Christine Goffinet, Christian Drosten
bioRxiv 2021.10.20.465121; doi: https://doi.org/10.1101/2021.10.20.465121
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