Article Information
History
- October 23, 2021.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Kaori Okaa,b,1,
- Shusuke Fujiokaa,b,1,
- Yoshimi Kawamuraa,b,1,
- Yoshihiro Komoharac,
- Takeshi Chujod,
- Koki Sekiguchia,
- Yuki Yamamuraa,
- Yuki Oiwaa,b,
- Natsuko Omamiuda-Ishikawaa,
- Shohei Komakie,
- Yoichi Sutohe,
- Satoko Sakuraif,
- Kazuhito Tomizawad,g,
- Hidemasa Bonoh,
- Atsushi Shimizue,i,
- Kimi Arakig,j,
- Takuya Yamamotof,k,l,m,
- Yasuhiro Yamadam,n,
- Hiroyuki Oshiumio and
- Kyoko Miuraa,b,g,*
- aDepartment of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-0811, Japan
- bBiomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan
- cDepartment of Cell Pathology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
- dDepartment of Molecular Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
- eDivision of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Iwate 028-3694, Japan
- fDepartment of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
- gCenter for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto 860-8556, Japan
- hProgram of Biomedical Science, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-0046, Japan
- iDivision of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, Iwate 028-3694, Japan
- jInstitute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan
- kInstitute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto 606-8501, Japan
- lMedical-risk Avoidance based on iPS Cells Team, RIKEN Center for Advanced Intelligence Project (AIP), Kyoto 606-8507, Japan
- mAMED-CREST, AMED, Tokyo 100-0004, Japan
- nDivision of Stem Cell Pathology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
- oDepartment of Immunology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan
- ↵*Corresponding author: Kyoko Miura. Email:
miurak{at}kumamoto-u.ac.jp
↵1 K.O., S.F. and Y. Kawamura contributed equally to this work.
Author Contributions: KO, SF, and Y Kawamura conducted most experiments; TC, KS, Y Yamamura, YO, NO-I, SK, YS, HB, and AS conducted certain experiments and analyses; Y Komohara and Y Yamada conducted histopathological analyses; SS and TY conducted RNA-seq analyses; HO analyzed sequences of components of necroptosis pathway; KA generated Ripk3 KO mice; KO, SF, Y Kawamura, Y Yamada, HO, and KM contributed to the study design; SF, KO, Y Kawamura, TC, KT, and KM wrote the manuscript; KM supervised the project.
Competing Interest Statement: The authors declare that they have no competing interests.