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A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition
Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Alexey Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
doi: https://doi.org/10.1101/2021.10.22.465184
Yadira M. Soto-Feliciano
1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY 10065, USA
Francisco J. Sánchez-Rivera
2Cancer Biology and Genetics, MSKCC New York, NY 10065, USA
Florian Perner
3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA., 02215, USA
4Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, 02215, USA
5Internal Medicine C, Greifswald University Medical Center, Greifswald, 17475, Germany
Douglas W. Barrows
1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY 10065, USA
6Bioinformatics Resource Center, The Rockefeller University, New York, NY 10065, USA
Edward R. Kastenhuber
2Cancer Biology and Genetics, MSKCC New York, NY 10065, USA
Yu-Jui Ho
2Cancer Biology and Genetics, MSKCC New York, NY 10065, USA
Thomas Carroll
6Bioinformatics Resource Center, The Rockefeller University, New York, NY 10065, USA
Yijun Xiong
3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA., 02215, USA
4Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, 02215, USA
Alexey Soshnev
1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY 10065, USA
Leah Gates
1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY 10065, USA
Mary Clare Beytagh
1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY 10065, USA
David Cheon
1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY 10065, USA
Shengqing Gu
7Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, 02215, MA, USA
8Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, 02215, MA, USA
X. Shirley Liu
7Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, 02215, MA, USA
8Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, 02215, MA, USA
Andrei V. Krivtsov
3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA., 02215, USA
4Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, 02215, USA
Maximiliano Meneses
9Department of Molecular Pharmacology, MSKCC New York, NY 10065, USA
Elisa de Stanchina
9Department of Molecular Pharmacology, MSKCC New York, NY 10065, USA
Richard M. Stone
10Leukemia Division, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA
Scott A. Armstrong
3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA., 02215, USA
4Division of Hematology/Oncology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, 02215, USA
Scott W. Lowe
2Cancer Biology and Genetics, MSKCC New York, NY 10065, USA
C. David Allis
1Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, NY 10065, USA
Article usage
Posted October 22, 2021.
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition
Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Alexey Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
bioRxiv 2021.10.22.465184; doi: https://doi.org/10.1101/2021.10.22.465184
A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition
Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Alexey Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
bioRxiv 2021.10.22.465184; doi: https://doi.org/10.1101/2021.10.22.465184
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