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Long-term stability of neural activity in the motor system

View ORCID ProfileKristopher T. Jensen, Naama Kadmon Harpaz, Ashesh K. Dhawale, Steffen B. E. Wolff, Bence P. Ölveczky
doi: https://doi.org/10.1101/2021.10.27.465945
Kristopher T. Jensen
1Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University
2Computational and Biological Learning Lab, Department of Engineering, University of Cambridge
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  • ORCID record for Kristopher T. Jensen
Naama Kadmon Harpaz
1Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University
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Ashesh K. Dhawale
1Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University
3Centre for Neuroscience, Indian Institute of Science, Bangalore, India
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Steffen B. E. Wolff
1Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University
4Department of Pharmacology, University of Maryland School of Medicine, Baltimore MD 21201, USA
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Bence P. Ölveczky
1Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University
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  • For correspondence: olveczky@fas.harvard.edu
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Abstract

How an established behavior is retained and stably produced by a nervous system in constant flux remains a mystery. One possible solution is to fix the activity patterns of single neurons in the relevant circuits. Alternatively, activity in single cells could drift over time provided that the population dynamics are constrained to produce stable behavior. To arbitrate between these possibilities, we recorded single unit activity in motor cortex and striatum continuously for several weeks as rats performed stereotyped motor behaviors – both learned and innate. We found long-term stability in behaviorally-locked single neuron activity patterns across both brain regions. A small amount of neural drift observed over weeks of recording could be explained by concomitant changes in task-irrelevant behavioral output. These results suggest that stereotyped behaviors are generated by stable neural activity patterns.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted March 28, 2022.
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Long-term stability of neural activity in the motor system
Kristopher T. Jensen, Naama Kadmon Harpaz, Ashesh K. Dhawale, Steffen B. E. Wolff, Bence P. Ölveczky
bioRxiv 2021.10.27.465945; doi: https://doi.org/10.1101/2021.10.27.465945
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Long-term stability of neural activity in the motor system
Kristopher T. Jensen, Naama Kadmon Harpaz, Ashesh K. Dhawale, Steffen B. E. Wolff, Bence P. Ölveczky
bioRxiv 2021.10.27.465945; doi: https://doi.org/10.1101/2021.10.27.465945

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