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Neurons in human pre-supplementary motor area encode key computations for value-based choice

Tomas G. Aquino, View ORCID ProfileJeffrey Cockburn, Adam N. Mamelak, Ueli Rutishauser, John P. O’Doherty
doi: https://doi.org/10.1101/2021.10.27.466000
Tomas G. Aquino
1Computation and Neural Systems, Division of Biology and Biological Engineering, California Institute of Technology, 91125
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  • For correspondence: taquino@caltech.edu
Jeffrey Cockburn
2Division of Humanities and Social Sciences, California Institute of Technology, 91125
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  • ORCID record for Jeffrey Cockburn
Adam N. Mamelak
3Department of Neurosurgery, Cedars-Sinai Medical Center, 90048
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Ueli Rutishauser
1Computation and Neural Systems, Division of Biology and Biological Engineering, California Institute of Technology, 91125
3Department of Neurosurgery, Cedars-Sinai Medical Center, 90048
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John P. O’Doherty
1Computation and Neural Systems, Division of Biology and Biological Engineering, California Institute of Technology, 91125
2Division of Humanities and Social Sciences, California Institute of Technology, 91125
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Abstract

Adaptive behavior in real-world environments demands that choices integrate over several variables, including the novelty of the options under consideration, their expected value, and uncertainty in value estimation. We recorded neurons from the human pre-supplementary motor area (preSMA), ventromedial prefrontal cortex (vmPFC) and dorsal anterior cingulate to probe how integration over decision variables occurs during decision-making. In contrast to the other areas, preSMA neurons not only represented separate pre-decision variables for each choice option, but also encoded an integrated utility signal and, subsequently, the decision itself. Conversely, post-decision related encoding of variables for the chosen option was more widely distributed and especially prominent in vmPFC. Our findings position the human preSMA as central to the implementation of value-based decisions.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵† Joint senior authors

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 28, 2021.
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Neurons in human pre-supplementary motor area encode key computations for value-based choice
Tomas G. Aquino, Jeffrey Cockburn, Adam N. Mamelak, Ueli Rutishauser, John P. O’Doherty
bioRxiv 2021.10.27.466000; doi: https://doi.org/10.1101/2021.10.27.466000
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Neurons in human pre-supplementary motor area encode key computations for value-based choice
Tomas G. Aquino, Jeffrey Cockburn, Adam N. Mamelak, Ueli Rutishauser, John P. O’Doherty
bioRxiv 2021.10.27.466000; doi: https://doi.org/10.1101/2021.10.27.466000

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