ABSTRACT
Dramatic rectal temperature decrease, in mice administered with a drug that specifically inhibits F1F0 ATP hydrolysis, suggests that F1F0 ATP hydrolysis is a major determinant of metabolic rate in vivo. Across twelve investigated species, less F1F0 ATP hydrolysis correlates with greater maximal lifespan. Specific drug inhibition of F1F0 ATP hydrolysis exerts potent anti-cancer activity in vitro.
Competing Interest Statement
The author has filed for related patents.
Footnotes
[1] Added anti-cancer content: pages 28-40. And updated title and abstract accordingly. [2] In the Methods section: added synthesis of compounds 7a and 7b, and added spectral data for compounds 6a, 7a and 7b. [3] Updated Competing Interests section with the new information that one of the author's related patent applications (in Australia) has now passed examination and been accepted. [4] Some minor, somewhat cosmetic changes, in some places.