New Results
Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara expressing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells
Ning Yang, Yi Wang, Shuaitong Liu, Joseph M. Luna, View ORCID ProfileGregory Mazo, Adrian Y. Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Rossi, Jenny Zhaoying Xiang, View ORCID ProfileCharles M. Rice, Taha Merghoub, Jedd D. Wolchok, View ORCID ProfileLiang Deng
doi: https://doi.org/10.1101/2021.10.31.466698
Ning Yang
1Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Yi Wang
1Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Shuaitong Liu
1Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Joseph M. Luna
3The Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, 10065, USA
Gregory Mazo
1Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Adrian Y. Tan
4Genomic Resources Core Facility, Weill Cornell Medical College, New York, NY, 10065, USA
Tuo Zhang
4Genomic Resources Core Facility, Weill Cornell Medical College, New York, NY, 10065, USA
Jiahu Wang
5Genvira Biosciences, Ottawa, ON K1V 1C1, Canada
Wei Yan
6IMVAQ Therapeutics, Sammamish, WA, 98021, USA
John Choi
6IMVAQ Therapeutics, Sammamish, WA, 98021, USA
Anthony Rossi
1Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
2Weill Cornell Medical College, New York, NY 10065
Jenny Zhaoying Xiang
4Genomic Resources Core Facility, Weill Cornell Medical College, New York, NY, 10065, USA
Charles M. Rice
3The Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, 10065, USA
Taha Merghoub
2Weill Cornell Medical College, New York, NY 10065
7Immuno-oncology service, Human Oncology and Pathogenesis Program; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
8Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Jedd D. Wolchok
2Weill Cornell Medical College, New York, NY 10065
7Immuno-oncology service, Human Oncology and Pathogenesis Program; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
8Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Liang Deng
1Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
2Weill Cornell Medical College, New York, NY 10065
8Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Posted November 01, 2021.
Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara expressing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells
Ning Yang, Yi Wang, Shuaitong Liu, Joseph M. Luna, Gregory Mazo, Adrian Y. Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Rossi, Jenny Zhaoying Xiang, Charles M. Rice, Taha Merghoub, Jedd D. Wolchok, Liang Deng
bioRxiv 2021.10.31.466698; doi: https://doi.org/10.1101/2021.10.31.466698
Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara expressing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells
Ning Yang, Yi Wang, Shuaitong Liu, Joseph M. Luna, Gregory Mazo, Adrian Y. Tan, Tuo Zhang, Jiahu Wang, Wei Yan, John Choi, Anthony Rossi, Jenny Zhaoying Xiang, Charles M. Rice, Taha Merghoub, Jedd D. Wolchok, Liang Deng
bioRxiv 2021.10.31.466698; doi: https://doi.org/10.1101/2021.10.31.466698
Subject Area
Subject Areas
- Biochemistry (11745)
- Bioengineering (8751)
- Bioinformatics (29195)
- Biophysics (14971)
- Cancer Biology (12095)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14179)
- Epidemiology (2067)
- Evolutionary Biology (18306)
- Genetics (12245)
- Genomics (16802)
- Immunology (11867)
- Microbiology (28083)
- Molecular Biology (11592)
- Neuroscience (60965)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2885)
- Systems Biology (7339)
- Zoology (1651)