Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Coherent theta oscillations in the cerebellum and supplementary motor area mediate visuomotor adaptation

Elinor Tzvi, Leila Gajiyeva, Laura Bindel, Gesa Hartwigsen, Joseph Classen
doi: https://doi.org/10.1101/2021.11.01.466768
Elinor Tzvi
1Department of Neurology, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: elinor.tzvi-minker@medizin.uni-leipzig.de
Leila Gajiyeva
2Lise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Bindel
1Department of Neurology, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gesa Hartwigsen
2Lise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph Classen
1Department of Neurology, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

The cerebellum and its interaction with cortical areas play a key role in our ability to flexibly adapt a motor program in response to sensory input. Current knowledge about specific neural mechanisms underlying the process of visuomotor adaptation is however lacking. Using a novel placement of EEG electrodes to record electric activity from the cerebellum, we studied local cerebellar activity, as well as its coupling with neocortical activity to obtain direct neurophysiological markers of visuomotor adaptation in humans. We found increased theta (4-8Hz) power in “cerebellar” as well as cortical electrodes, when subjects first encountered a visual perturbation. Theta power decreased as subjects adapted to the perturbation, and rebounded when the perturbation was suddenly removed. This effect was observed in two distinct locations: a cerebellar cluster and a central cluster, which were localized in left cerebellar crus I (lCB) and right supplementary motor area (rSMA) using linear constrained minimum variance beamforming. Importantly, we found that better adaptation was associated with increased theta power in left cerebellar electrodes and a right sensorimotor cortex electrode. Finally, increased rSMA –> lCB connectivity was significantly decreased with adaptation. These results demonstrate that: (1) cerebellar theta power is markedly modulated over the course of visuomotor adaptation and (2) theta oscillations could serve as a key mechanism for communication within a cortico-cerebellar loop.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted November 02, 2021.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Coherent theta oscillations in the cerebellum and supplementary motor area mediate visuomotor adaptation
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Coherent theta oscillations in the cerebellum and supplementary motor area mediate visuomotor adaptation
Elinor Tzvi, Leila Gajiyeva, Laura Bindel, Gesa Hartwigsen, Joseph Classen
bioRxiv 2021.11.01.466768; doi: https://doi.org/10.1101/2021.11.01.466768
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Coherent theta oscillations in the cerebellum and supplementary motor area mediate visuomotor adaptation
Elinor Tzvi, Leila Gajiyeva, Laura Bindel, Gesa Hartwigsen, Joseph Classen
bioRxiv 2021.11.01.466768; doi: https://doi.org/10.1101/2021.11.01.466768

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4224)
  • Biochemistry (9101)
  • Bioengineering (6749)
  • Bioinformatics (23935)
  • Biophysics (12086)
  • Cancer Biology (9491)
  • Cell Biology (13738)
  • Clinical Trials (138)
  • Developmental Biology (7614)
  • Ecology (11656)
  • Epidemiology (2066)
  • Evolutionary Biology (15476)
  • Genetics (10615)
  • Genomics (14292)
  • Immunology (9456)
  • Microbiology (22773)
  • Molecular Biology (9069)
  • Neuroscience (48840)
  • Paleontology (354)
  • Pathology (1479)
  • Pharmacology and Toxicology (2562)
  • Physiology (3822)
  • Plant Biology (8307)
  • Scientific Communication and Education (1467)
  • Synthetic Biology (2289)
  • Systems Biology (6170)
  • Zoology (1297)