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Violet light modulates the central nervous system to regulate memory and mood

Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A. Lang, Masaru Mimura, Kazuo Tsubota
doi: https://doi.org/10.1101/2021.11.02.466604
Nobunari Sasaki
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Pooja Gusain
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Motoshi Hayano
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
2Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
3Faculty of Science and Technology, Keio University, Yokohama, Japan
4Tsubota Laboratory, Inc., Tokyo, Japan
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  • For correspondence: mhayano@keio.jp
Tetsuro Sugaya
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Naoya Tonegawa
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Yusuke Hatanaka
4Tsubota Laboratory, Inc., Tokyo, Japan
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Risako Tamura
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Kei Okuyama
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Hideto Osada
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Norimitsu Ban
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
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Yasue Mitsukura
3Faculty of Science and Technology, Keio University, Yokohama, Japan
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Richard A. Lang
5Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
6Department of Ophthalmology, University of Cincinnati, College of Medicine, Cincinnati, OH, USA
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Masaru Mimura
2Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
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Kazuo Tsubota
1Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
4Tsubota Laboratory, Inc., Tokyo, Japan
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  • For correspondence: mhayano@keio.jp
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Abstract

Light stimuli from the external environment serves as a signal. Photoreceptors receive photons at the outer nuclear layer of the retina. Non-visual photoreceptors, such as opsin5 (also known as OPN5 or neuropsin), are expressed in the retinal ganglion cells (RGCs) and hypothalamus to regulate the circadian cycle and body temperature. Here, we show that violet light (VL) stimuli received by OPN5-positive RGCs are transmitted to the habenula brain region. VL improves memory in aged mice and simultaneously increases neural architecture-related genes such as oligodendrocyte-related genes in the hippocampus. In addition, VL improves depressive-like behaviors in the social defeat stress model in an OPN5 dependent manner. Following VL exposure, cFos activation is observed at the nucleus accumbens (NAc) and the paraventricular thalamic nucleus (PVT). Taken together, the results indicate that violet light modulates brain function such as memory and mood by transmitting the signal from RGCs to the habenula region in the brain.

Competing Interest Statement

K. T. reports he is the CEO of Tsubota Laboratory, Inc. K. T., M. H. and Y. M. owns the unlisted stocks of Tsubota Laboratory, Inc., a company developing devices related to violet light. R. A. L. has a sponsored research agreement with BIOS Lighting and, in collaboration with BIOS Lighting, has submitted patent application 41906194/PCT/US21/17681, Lighting Devices to Promote Circadian Health. Y. H. is an employee of the Tsubota Laboratory Inc. Tsubota Laboratory, Inc. consigns the experiment to N. S., P. G. M. H. and K. O. Other authors declare no conflicts of interest associated with this manuscript.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 04, 2021.
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Violet light modulates the central nervous system to regulate memory and mood
Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A. Lang, Masaru Mimura, Kazuo Tsubota
bioRxiv 2021.11.02.466604; doi: https://doi.org/10.1101/2021.11.02.466604
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Violet light modulates the central nervous system to regulate memory and mood
Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A. Lang, Masaru Mimura, Kazuo Tsubota
bioRxiv 2021.11.02.466604; doi: https://doi.org/10.1101/2021.11.02.466604

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