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Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data

Junko Yamane, Takumi Wada, Hironori Otsuki, Koji Inomata, Mutsumi Suzuki, Tomoka Hisaki, Shuichi Sekine, Hirokazu Kouzuki, Kenta Kobayashi, Hideko Sone, Jun K. Yamashita, Mitsujiro Osawa, Megumu K. Saito, Wataru Fujibuchi
doi: https://doi.org/10.1101/2021.11.05.466718

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doi 
https://doi.org/10.1101/2021.11.05.466718
History 
  • November 5, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Junko Yamane1,
  2. Takumi Wada1,
  3. Hironori Otsuki2,
  4. Koji Inomata2,
  5. Mutsumi Suzuki2,
  6. Tomoka Hisaki3,
  7. Shuichi Sekine3,
  8. Hirokazu Kouzuki3,
  9. Kenta Kobayashi1,
  10. Hideko Sone4,
  11. Jun K. Yamashita1,
  12. Mitsujiro Osawa1,
  13. Megumu K. Saito1 and
  14. Wataru Fujibuchi1,*,†
  1. 1Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
  2. 2Toxicological Research Laboratories, Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan
  3. 3MIRAI Technology Institute, Shiseido Co., Ltd., 1-2-11, Takashima, Nishi-ku, Yokohama-shi, Kanagawa 220-0011, Japan
  4. 4Environmental Health and Prevention Research Unit, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama-shi, Kanagawa 245-0066, Japan
  1. ↵† Corresponding author; email: w.fujibuchi{at}cira.kyoto-u.ac.jp

  • ↵* Additional Footnotes Present address: Contact Wataru Fujibuchi, Address: Center for iPS Cell Research and Application (CiRA), Kyoto University, 53, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan, fujibuchi-g{at}cira.kyoto-u.ac.jp Tel: +81-75-366-7012

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Posted November 05, 2021.
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Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data
Junko Yamane, Takumi Wada, Hironori Otsuki, Koji Inomata, Mutsumi Suzuki, Tomoka Hisaki, Shuichi Sekine, Hirokazu Kouzuki, Kenta Kobayashi, Hideko Sone, Jun K. Yamashita, Mitsujiro Osawa, Megumu K. Saito, Wataru Fujibuchi
bioRxiv 2021.11.05.466718; doi: https://doi.org/10.1101/2021.11.05.466718
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