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Once-daily feeding is associated with better cognitive function and health in companion dogs: Results from the Dog Aging Project

View ORCID ProfileEmily E. Bray, Zihan Zheng, View ORCID ProfileM. Katherine Tolbert, Brianah M. McCoy, Dog Aging Project Consortium, View ORCID ProfileMatt Kaeberlein, View ORCID ProfileKathleen F. Kerr
doi: https://doi.org/10.1101/2021.11.08.467616
Emily E. Bray
1Arizona Canine Cognition Center, School of Anthropology, University of Arizona, Tucson, AZ, USA
2Canine Companions for Independence, National Headquarters, Santa Rosa, CA, USA
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Zihan Zheng
3Department of Biostatistics, University of Washington, Seattle, WA, USA
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M. Katherine Tolbert
4Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A&M University, College Station, TX, USA
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Brianah M. McCoy
5School of Life Sciences, Arizona State University, Tempe, AZ, USA
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Matt Kaeberlein
6Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA
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Kathleen F. Kerr
3Department of Biostatistics, University of Washington, Seattle, WA, USA
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  • For correspondence: katiek@uw.edu
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Abstract

A variety of diets have been studied for possible anti-aging effects. In particular, studies of isocaloric time-restricted feeding in laboratory rodents have found evidence of beneficial health outcomes. Companion dogs represent a unique opportunity to study diet in a large mammal that shares human environments. The Dog Aging Project has been collecting data on thousands of companion dogs of all different ages, sizes, and breeds since 2019. We leveraged this diverse cross-sectional dataset to investigate associations between feeding frequency and cognitive function (n = 10,474) as well as nine broad categories of health outcomes (n = 24,238). Controlling for sex, age, breed, and other potential confounders, we found that dogs fed once daily rather than more frequently had lower mean scores on a cognitive dysfunction scale, and lower odds of having gastrointestinal, dental, orthopedic, kidney/urinary, and liver/pancreas disorders. Therefore, our findings suggest that once-a-day feeding in dogs is associated with improved health across multiple body systems.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 11, 2021.
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Once-daily feeding is associated with better cognitive function and health in companion dogs: Results from the Dog Aging Project
Emily E. Bray, Zihan Zheng, M. Katherine Tolbert, Brianah M. McCoy, Dog Aging Project Consortium, Matt Kaeberlein, Kathleen F. Kerr
bioRxiv 2021.11.08.467616; doi: https://doi.org/10.1101/2021.11.08.467616
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Once-daily feeding is associated with better cognitive function and health in companion dogs: Results from the Dog Aging Project
Emily E. Bray, Zihan Zheng, M. Katherine Tolbert, Brianah M. McCoy, Dog Aging Project Consortium, Matt Kaeberlein, Kathleen F. Kerr
bioRxiv 2021.11.08.467616; doi: https://doi.org/10.1101/2021.11.08.467616

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