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Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2

Oscar Rosas Mejia, Erin S. Gloag, Jianying Li, Marisa Ruane-Foster, Tiffany A. Claeys, Daniela Farkas, Laszlo Farkas, Gang Xin, View ORCID ProfileRichard T. Robinson
doi: https://doi.org/10.1101/2021.11.09.467862
Oscar Rosas Mejia
1Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA
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Erin S. Gloag
1Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA
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Jianying Li
2Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA
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Marisa Ruane-Foster
1Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA
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Tiffany A. Claeys
1Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA
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Daniela Farkas
3Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
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Laszlo Farkas
3Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
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Gang Xin
1Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA
2Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, USA
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Richard T. Robinson
1Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA
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  • ORCID record for Richard T. Robinson
  • For correspondence: richard.robinson@osumc.edu
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ABSTRACT

Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are the leading causes of death due to infectious disease. Although Mtb and CoV2 both cause serious and sometimes fatal respiratory infections, the effect of Mtb infection and its associated immune response on secondary infection with CoV2 is unknown. To address this question we applied two mouse models of COVID19, using mice which were chronically infected with Mtb. In both model systems, Mtb-infected mice were resistant to secondary CoV2 infection and its pathological consequences, and CoV2 infection did not affect Mtb burdens. Single cell RNA sequencing of coinfected and monoinfected lungs demonstrated the resistance of Mtb-infected mice is associated with expansion of T and B cell subsets upon viral challenge. Collectively, these data demonstrate that Mtb infection conditions the lung environment in a manner that is not conducive to CoV2 survival.

AUTHOR SUMMARY Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are distinct organisms which both cause lung disease. We report the surprising observation that Mtb-infected mice are resistant to secondary infection with CoV2, with no impact on Mtb burden and resistance associating with lung T and B cell expansion.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted November 10, 2021.
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Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2
Oscar Rosas Mejia, Erin S. Gloag, Jianying Li, Marisa Ruane-Foster, Tiffany A. Claeys, Daniela Farkas, Laszlo Farkas, Gang Xin, Richard T. Robinson
bioRxiv 2021.11.09.467862; doi: https://doi.org/10.1101/2021.11.09.467862
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Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2
Oscar Rosas Mejia, Erin S. Gloag, Jianying Li, Marisa Ruane-Foster, Tiffany A. Claeys, Daniela Farkas, Laszlo Farkas, Gang Xin, Richard T. Robinson
bioRxiv 2021.11.09.467862; doi: https://doi.org/10.1101/2021.11.09.467862

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