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Heritability of hippocampal functional and microstructural organisation

Şeyma Bayrak, View ORCID ProfileReinder Vos de Wael, View ORCID ProfileH. Lina Schaare, Meike D. Hettwer, Benoit Caldairou, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt, View ORCID ProfileSofie L. Valk
doi: https://doi.org/10.1101/2021.11.10.468049
Şeyma Bayrak
1Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04103, Germany
2Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich 52428, Germany
3Department of Cognitive Neurology, University Hospital Leipzig and Faculty of Medicine, University of Leipzig, Leipzig 04103, Germany
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  • For correspondence: bayrak@cbs.mpg.de valk@cbs.mpg.de
Reinder Vos de Wael
4Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
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  • ORCID record for Reinder Vos de Wael
H. Lina Schaare
1Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04103, Germany
2Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich 52428, Germany
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  • ORCID record for H. Lina Schaare
Meike D. Hettwer
1Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04103, Germany
2Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich 52428, Germany
5Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
6Max Planck School of Cognition, Max Planck Institute of Human Cognitive and Brain Sciences, Leipzig 04103, Germany
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Benoit Caldairou
7Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
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Andrea Bernasconi
7Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
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Neda Bernasconi
7Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
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Boris C. Bernhardt
4Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
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Sofie L. Valk
1Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04103, Germany
2Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich 52428, Germany
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  • ORCID record for Sofie L. Valk
  • For correspondence: bayrak@cbs.mpg.de valk@cbs.mpg.de
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Abstract

The hippocampus is a uniquely infolded allocortical structure in the medial temporal lobe that consists of the microstructurally and functionally distinct subregions: subiculum, cornu ammonis, and dentate gyrus. The hippocampus is a remarkably plastic region that is implicated in learning and memory. At the same time it has been shown that hippocampal subregion volumes are heritable, and that genetic expression varies along a posterior to anterior axis. Here, we studied how a heritable, stable, hippocampal organisation may support its flexible function in healthy adults. Leveraging the twin set-up of the Human Connectome Project with multimodal neuroimaging, we observed that the functional connectivity between hippocampus and cortex was heritable and that microstructure of the hippocampus genetically correlated with cortical microstructure. Moreover, both functional and microstructural organisation could be consistently captured by anterior-to-posterior and medial-to-lateral axes across individuals. However, heritability of functional, relative to microstructural, organisation was found reduced, suggesting individual variation in functional organisation of subfields is under low genetic control. Last, we demonstrate that structure and function couple along its genetic axes, suggesting an interplay of stability and plasticity within the hippocampus. Our study provides new insights on the heritability of the hippocampal formation and illustrates how genetic axes may scaffold hippocampal structure and function.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Gradient alignment was erroneous, this has been corrected.

  • https://github.com/CNG-LAB/cngopen/tree/main/hippocampus

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 12, 2022.
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Heritability of hippocampal functional and microstructural organisation
Şeyma Bayrak, Reinder Vos de Wael, H. Lina Schaare, Meike D. Hettwer, Benoit Caldairou, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt, Sofie L. Valk
bioRxiv 2021.11.10.468049; doi: https://doi.org/10.1101/2021.11.10.468049
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Heritability of hippocampal functional and microstructural organisation
Şeyma Bayrak, Reinder Vos de Wael, H. Lina Schaare, Meike D. Hettwer, Benoit Caldairou, Andrea Bernasconi, Neda Bernasconi, Boris C. Bernhardt, Sofie L. Valk
bioRxiv 2021.11.10.468049; doi: https://doi.org/10.1101/2021.11.10.468049

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