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GutMicroNet: an interactive platform for gut microbiome interaction exploration

View ORCID ProfileMuhammad Arif, Theo Portlock, Cem Güngör, Elif Koç, Berkay Özcan, Oğuzhan Subaş, Buğra Çakmak, Hassan Turkez, Mathias Uhlén, Adil Mardinoglu, Saeed Shoaie
doi: https://doi.org/10.1101/2021.11.10.468051
Muhammad Arif
1Science for Life Laboratory, KTH – Royal Institute of Technology, Stockholm, SE-171 21, Sweden
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  • ORCID record for Muhammad Arif
Theo Portlock
1Science for Life Laboratory, KTH – Royal Institute of Technology, Stockholm, SE-171 21, Sweden
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Cem Güngör
2Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA, USA
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Elif Koç
2Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA, USA
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Berkay Özcan
2Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA, USA
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Oğuzhan Subaş
2Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA, USA
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Buğra Çakmak
2Bash Biotech Inc, 600 West Broadway, Suite 700, San Diego, CA, USA
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Hassan Turkez
3Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey
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Mathias Uhlén
1Science for Life Laboratory, KTH – Royal Institute of Technology, Stockholm, SE-171 21, Sweden
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Adil Mardinoglu
1Science for Life Laboratory, KTH – Royal Institute of Technology, Stockholm, SE-171 21, Sweden
4Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, SE1 9RT, UK
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  • For correspondence: saeed.shoaie@scilifelab.se adilm@scilifelab.se
Saeed Shoaie
1Science for Life Laboratory, KTH – Royal Institute of Technology, Stockholm, SE-171 21, Sweden
4Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, SE1 9RT, UK
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  • For correspondence: saeed.shoaie@scilifelab.se adilm@scilifelab.se
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ABSTRACT

The human gut microbiome data has been proven to be a powerful tool to understand the human body in both health and disease conditions. However, understanding their complex interactions and impact on the human body remains a challenging task. Unravelling the species-level interactions could allow us to study the causality of the microbiome. Moreover, it could lead us to better understand the underlying mechanisms of complex diseases and, subsequently, the discovery of new therapeutic targets. Given these challenges and benefits, it has become evident that a freely accessible and centralized platform for presenting gut microbiome interaction is essential to untangle the complexity and open multiple new paths and opportunities in disease- and drug-related research. Here, we present GutMicroNet, an interactive visualization platform of human gut microbiome interaction networks. We generated 45 gut microbiome co-abundance networks from various geographical origins, gender, and diseases based on the data presented in the Human Gut Microbiome Atlas. This interactive platform includes more than 1900 gut microbiome species and allows users to query multiple species at the same time based on their interests and adjust it based on the statistical properties. Moreover, users can download publication-ready figures or network information for further analysis. The platform can be accessed freely on https://gutmicro.net without any login requirements or limitations, including access to the full networks data.

Competing Interest Statement

Cem Güngör, Elif Koç, Berkay Özcan, Oğuzhan Subaş, Buğra Çakmak are the employees of Bash Biotech Inc, San Diego, CA, USA. Buğra Çakmak, Hasan Turkez, Adil Mardinoglu and Saeed Shoaie are the co-founders of Bash Biotech Inc. The other authors declare no conflict of interest.

Footnotes

  • ↵† The authors wish it to be known that, in their opinion, the first two authors should be regarded as Joint First Authors.

  • Adding a missing author from previous submission

  • https://gutmicro.net

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 12, 2021.
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GutMicroNet: an interactive platform for gut microbiome interaction exploration
Muhammad Arif, Theo Portlock, Cem Güngör, Elif Koç, Berkay Özcan, Oğuzhan Subaş, Buğra Çakmak, Hassan Turkez, Mathias Uhlén, Adil Mardinoglu, Saeed Shoaie
bioRxiv 2021.11.10.468051; doi: https://doi.org/10.1101/2021.11.10.468051
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GutMicroNet: an interactive platform for gut microbiome interaction exploration
Muhammad Arif, Theo Portlock, Cem Güngör, Elif Koç, Berkay Özcan, Oğuzhan Subaş, Buğra Çakmak, Hassan Turkez, Mathias Uhlén, Adil Mardinoglu, Saeed Shoaie
bioRxiv 2021.11.10.468051; doi: https://doi.org/10.1101/2021.11.10.468051

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