Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation

Macarena S. Arrázola; Matías Lira; Gabriel Quiroz; Somya Iqbal; Samantha L Eaton; Rachel A Kline; Douglas J Lamont; Hernán Huerta; Gonzalo Ureta; Sebastián Bernales; J César Cárdenas; Waldo Cerpa; Thomas M. Wishart; Felipe A. Court

doi:10.1101/2021.11.10.468052

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Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation

View ORCID ProfileMacarena S. Arrázola, View ORCID ProfileMatías Lira, View ORCID ProfileGabriel Quiroz, Somya Iqbal, Samantha L Eaton, Rachel A Kline, Douglas J Lamont, Hernán Huerta, View ORCID ProfileGonzalo Ureta, Sebastián Bernales, J César Cárdenas, View ORCID ProfileWaldo Cerpa, View ORCID ProfileThomas M. Wishart, View ORCID ProfileFelipe A. Court

doi: https://doi.org/10.1101/2021.11.10.468052

Macarena S. Arrázola

1Center for Integrative Biology, Faculty of Sciences, Universidad Mayor

2Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile

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Matías Lira

3Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O’Higgins 340, Santiago, Chile

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Gabriel Quiroz

2Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile

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Somya Iqbal

4The Roslin Institute, University of Edinburgh, Edinburgh, UK

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Samantha L Eaton

4The Roslin Institute, University of Edinburgh, Edinburgh, UK

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Rachel A Kline

4The Roslin Institute, University of Edinburgh, Edinburgh, UK

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Douglas J Lamont

4The Roslin Institute, University of Edinburgh, Edinburgh, UK

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Hernán Huerta

1Center for Integrative Biology, Faculty of Sciences, Universidad Mayor

2Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile

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Gonzalo Ureta

5Fundación Ciencia & Vida, Santiago, Chile

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Sebastián Bernales

5Fundación Ciencia & Vida, Santiago, Chile

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J César Cárdenas

1Center for Integrative Biology, Faculty of Sciences, Universidad Mayor

2Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile

6Buck Institute for Research on Aging, Novato, CA, USA

7Department of Chemistry and Biochemistry, University of California, Santa Barbara, California, USA

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Waldo Cerpa

3Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O’Higgins 340, Santiago, Chile

8Centro de Excelencia en Biomedicina de Magallanes (CEBIMA), Universidad de Magallanes, Punta Arenas, Chile

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Thomas M. Wishart

4The Roslin Institute, University of Edinburgh, Edinburgh, UK

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Felipe A. Court

1Center for Integrative Biology, Faculty of Sciences, Universidad Mayor

2Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile

6Buck Institute for Research on Aging, Novato, CA, USA

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Posted April 18, 2022.

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Necroptosis inhibition counteracts axonal degeneration, cognitive decline and key hallmarks of aging, promoting brain rejuvenation

Macarena S. Arrázola, Matías Lira, Gabriel Quiroz, Somya Iqbal, Samantha L Eaton, Rachel A Kline, Douglas J Lamont, Hernán Huerta, Gonzalo Ureta, Sebastián Bernales, J César Cárdenas, Waldo Cerpa, Thomas M. Wishart, Felipe A. Court

bioRxiv 2021.11.10.468052; doi: https://doi.org/10.1101/2021.11.10.468052

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