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Subiculum – BNST Structural Connectivity in Humans and Macaques

View ORCID ProfileSamuel C. Berry, Andrew D. Lawrence, View ORCID ProfileThomas M. Lancaster, Chiara M. Casella, View ORCID ProfileJohn P. Aggleton, Mark Postans
doi: https://doi.org/10.1101/2021.11.11.468209
Samuel C. Berry
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
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  • For correspondence: berrysc@cardiff.ac.uk
Andrew D. Lawrence
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
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Thomas M. Lancaster
2School of Psychology, University of Bath, Bath, UK
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Chiara M. Casella
3Department of Perinatal Imaging and Health, School of Biomedical Engineering & Imaging Sciences, Kings College London, London, UK
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John P. Aggleton
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
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Mark Postans
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
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Abstract

Invasive tract-tracing studies in rodents implicate a direct connection between the subiculum and bed nucleus of the stria terminalis (BNST) as a key component of neural pathways mediating hippocampal regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. A clear characterisation of the connections linking the subiculum and BNST in humans and non-human primates is lacking. To address this, we first delineated the projections from the subiculum to the BNST using anterograde tracers injected into macaque monkeys, revealing evidence for a monosynaptic subiculum-BNST projection involving the fornix. Second, we used in vivo diffusion MRI tractography in macaques and humans to demonstrate substantial subiculum complex connectivity to the BNST in both species. This connection was primarily mediated through the fornix, with additional connectivity via the amygdala, consistent with rodent anatomy. Third, utilising the twin-based nature of our human sample, we found that microstructural properties of these tracts are moderately heritable (h2 ∼ 0.5). In a final analysis, we found no evidence of any significant association between subiculum complex-BNST tract microstructure and indices of perceived stress/dispositional negativity and alcohol use, derived from principal component analysis decomposition of self-report data. We did, however, find subiculum complex-BNST tract microstructure associations with BMI, age, and sex. Our findings address a key translational gap in our knowledge of the neurocircuitry regulating stress.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://neurovault.org/collections/9001/

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 13, 2021.
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Subiculum – BNST Structural Connectivity in Humans and Macaques
Samuel C. Berry, Andrew D. Lawrence, Thomas M. Lancaster, Chiara M. Casella, John P. Aggleton, Mark Postans
bioRxiv 2021.11.11.468209; doi: https://doi.org/10.1101/2021.11.11.468209
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Subiculum – BNST Structural Connectivity in Humans and Macaques
Samuel C. Berry, Andrew D. Lawrence, Thomas M. Lancaster, Chiara M. Casella, John P. Aggleton, Mark Postans
bioRxiv 2021.11.11.468209; doi: https://doi.org/10.1101/2021.11.11.468209

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