Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells

Beau R. Webber; Matthew J. Johnson; Nicholas J. Slipek; Walker S. Lahr; Anthony P. DeFeo; Joseph G. Skeate; Xiaohong Qiu; Blaine Rathmann; Miechaleen D. Diers; Bryce Wick; Tom Henley; Modassir Choudhry; R. Scott McIvor; Branden S. Moriarity

doi:10.1101/2021.11.12.468427

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Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells

Beau R. Webber, Matthew J. Johnson, Nicholas J. Slipek, Walker S. Lahr, Anthony P. DeFeo, Joseph G. Skeate, Xiaohong Qiu, Blaine Rathmann, Miechaleen D. Diers, Bryce Wick, Tom Henley, Modassir Choudhry, R. Scott McIvor, Branden S. Moriarity

doi: https://doi.org/10.1101/2021.11.12.468427

Beau R. Webber

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Matthew J. Johnson

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Nicholas J. Slipek

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Walker S. Lahr

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Anthony P. DeFeo

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Joseph G. Skeate

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Xiaohong Qiu

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Blaine Rathmann

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Miechaleen D. Diers

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Bryce Wick

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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Tom Henley

4Intima Bioscience, New York, USA

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Modassir Choudhry

4Intima Bioscience, New York, USA

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R. Scott McIvor

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

5Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA

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Branden S. Moriarity

1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

2Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA

3Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA

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For correspondence: mori0164@umn.edu

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