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Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
Aereas Aung, Ang Cui, Ava P. Soleimany, Maurice Bukenya, Heya Lee, Christopher A. Cottrell, Murillo Silva, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Shuhao Xiao, Leah Michelle Froehle, Wuhbet Abraham, Josetta Adams, Heikyung Suh, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine
doi: https://doi.org/10.1101/2021.11.15.468669
Aereas Aung
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Ang Cui
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
Ava P. Soleimany
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
4Program in Biophysics, Harvard University, Boston, MA, USA
Maurice Bukenya
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Heya Lee
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Christopher A. Cottrell
5Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA
7Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA
Murillo Silva
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Jesse D. Kirkpatrick
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
Parastoo Amlashi
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Tanaka Remba
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Shuhao Xiao
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Leah Michelle Froehle
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
Wuhbet Abraham
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Josetta Adams
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Heikyung Suh
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
Phillip Huyett
11Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, USA
Douglas S. Kwon
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
Nir Hacohen
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
6Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
William R. Schief
7Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
9Dept. of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
10IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA
Sangeeta N. Bhatia
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
12Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
13Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
14Wyss Institute at Harvard, Boston, MA, USA
17Howard Hughes Medical Institute, Cambridge, MA, USA
Darrell J. Irvine
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
7Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
15Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
16Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
17Howard Hughes Medical Institute, Cambridge, MA, USA

- Supplementary Material[supplements/468669_file08.pdf]
Posted November 15, 2021.
Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
Aereas Aung, Ang Cui, Ava P. Soleimany, Maurice Bukenya, Heya Lee, Christopher A. Cottrell, Murillo Silva, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Shuhao Xiao, Leah Michelle Froehle, Wuhbet Abraham, Josetta Adams, Heikyung Suh, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine
bioRxiv 2021.11.15.468669; doi: https://doi.org/10.1101/2021.11.15.468669
Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
Aereas Aung, Ang Cui, Ava P. Soleimany, Maurice Bukenya, Heya Lee, Christopher A. Cottrell, Murillo Silva, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Shuhao Xiao, Leah Michelle Froehle, Wuhbet Abraham, Josetta Adams, Heikyung Suh, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine
bioRxiv 2021.11.15.468669; doi: https://doi.org/10.1101/2021.11.15.468669
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