Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

Aereas Aung, Ang Cui, Ava P. Soleimany, Maurice Bukenya, Heya Lee, Christopher A. Cottrell, Murillo Silva, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Shuhao Xiao, Leah Michelle Froehle, Wuhbet Abraham, Josetta Adams, Heikyung Suh, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine
doi: https://doi.org/10.1101/2021.11.15.468669
Aereas Aung
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ang Cui
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ava P. Soleimany
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
4Program in Biophysics, Harvard University, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maurice Bukenya
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heya Lee
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher A. Cottrell
5Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA
7Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Murillo Silva
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jesse D. Kirkpatrick
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Parastoo Amlashi
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanaka Remba
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shuhao Xiao
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leah Michelle Froehle
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wuhbet Abraham
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josetta Adams
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heikyung Suh
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Phillip Huyett
11Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Douglas S. Kwon
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nir Hacohen
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
6Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William R. Schief
7Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
9Dept. of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
10IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sangeeta N. Bhatia
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
2Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, USA
12Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
13Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
14Wyss Institute at Harvard, Boston, MA, USA
17Howard Hughes Medical Institute, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Darrell J. Irvine
1Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA
7Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA, USA
8Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
15Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
16Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
17Howard Hughes Medical Institute, Cambridge, MA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: djirvine@mit.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading
  • Supplementary Material[supplements/468669_file08.pdf]
Back to top
PreviousNext
Posted November 15, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
Aereas Aung, Ang Cui, Ava P. Soleimany, Maurice Bukenya, Heya Lee, Christopher A. Cottrell, Murillo Silva, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Shuhao Xiao, Leah Michelle Froehle, Wuhbet Abraham, Josetta Adams, Heikyung Suh, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine
bioRxiv 2021.11.15.468669; doi: https://doi.org/10.1101/2021.11.15.468669
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens
Aereas Aung, Ang Cui, Ava P. Soleimany, Maurice Bukenya, Heya Lee, Christopher A. Cottrell, Murillo Silva, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Shuhao Xiao, Leah Michelle Froehle, Wuhbet Abraham, Josetta Adams, Heikyung Suh, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine
bioRxiv 2021.11.15.468669; doi: https://doi.org/10.1101/2021.11.15.468669

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Immunology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4239)
  • Biochemistry (9172)
  • Bioengineering (6804)
  • Bioinformatics (24063)
  • Biophysics (12155)
  • Cancer Biology (9564)
  • Cell Biology (13825)
  • Clinical Trials (138)
  • Developmental Biology (7658)
  • Ecology (11737)
  • Epidemiology (2066)
  • Evolutionary Biology (15540)
  • Genetics (10672)
  • Genomics (14359)
  • Immunology (9511)
  • Microbiology (22901)
  • Molecular Biology (9129)
  • Neuroscience (49113)
  • Paleontology (357)
  • Pathology (1487)
  • Pharmacology and Toxicology (2583)
  • Physiology (3851)
  • Plant Biology (8351)
  • Scientific Communication and Education (1473)
  • Synthetic Biology (2301)
  • Systems Biology (6205)
  • Zoology (1302)