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Recent zoonotic spillover and tropism shift of a Canine Coronavirus is associated with relaxed selection and putative loss of function in NTD subdomain of spike protein

View ORCID ProfileJordan D. Zehr, View ORCID ProfileSergei L. Kosakovsky Pond, View ORCID ProfileDarren P. Martin, View ORCID ProfileKristina Ceres, View ORCID ProfileGary R. Whittaker, View ORCID ProfileLaura B. Goodman, View ORCID ProfileMichael J. Stanhope
doi: https://doi.org/10.1101/2021.11.15.468709
Jordan D. Zehr
1Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, 19122, USA
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Sergei L. Kosakovsky Pond
1Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, 19122, USA
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Darren P. Martin
2Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
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Kristina Ceres
3Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, 14853, USA
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  • ORCID record for Kristina Ceres
Gary R. Whittaker
4Department of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA
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Laura B. Goodman
5Baker Institute for Animal Health, Cornell University, Ithaca, NY, 14850, USA
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Michael J. Stanhope
3Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, 14853, USA
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  • ORCID record for Michael J. Stanhope
  • For correspondence: mjs297@cornell.edu
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Article Information

doi 
https://doi.org/10.1101/2021.11.15.468709
History 
  • November 17, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Jordan D. Zehr1,
  2. Sergei L. Kosakovsky Pond1,
  3. Darren P. Martin2,
  4. Kristina Ceres3,
  5. Gary R. Whittaker4,
  6. Laura B. Goodman5 and
  7. Michael J. Stanhope*,3
  1. 1Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA, 19122, USA
  2. 2Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Observatory, Cape Town, South Africa
  3. 3Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, 14853, USA
  4. 4Department of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA
  5. 5Baker Institute for Animal Health, Cornell University, Ithaca, NY, 14850, USA
  1. ↵*Author to whom correspondence should be addressed: mjs297{at}cornell.edu
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Posted November 17, 2021.
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Recent zoonotic spillover and tropism shift of a Canine Coronavirus is associated with relaxed selection and putative loss of function in NTD subdomain of spike protein
Jordan D. Zehr, Sergei L. Kosakovsky Pond, Darren P. Martin, Kristina Ceres, Gary R. Whittaker, Laura B. Goodman, Michael J. Stanhope
bioRxiv 2021.11.15.468709; doi: https://doi.org/10.1101/2021.11.15.468709
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Recent zoonotic spillover and tropism shift of a Canine Coronavirus is associated with relaxed selection and putative loss of function in NTD subdomain of spike protein
Jordan D. Zehr, Sergei L. Kosakovsky Pond, Darren P. Martin, Kristina Ceres, Gary R. Whittaker, Laura B. Goodman, Michael J. Stanhope
bioRxiv 2021.11.15.468709; doi: https://doi.org/10.1101/2021.11.15.468709

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