Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

View ORCID ProfileJaana Simola, Felix Siebenhühner, Vladislav Myrov, Katri Kantojärvi, Tiina Paunio, J. Matias Palva, Elvira Brattico, Satu Palva
doi: https://doi.org/10.1101/2021.11.16.468778
Jaana Simola
1Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, P.O. Box 21, (Haartmaninkatu 3), FI-00014 Helsinki, Finland
2Helsinki Collegium for Advanced Studies (HCAS), University of Helsinki, Finland
3BioMag Laboratory, HUS Medical Imaging Centre, FI-00029 HUS, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jaana Simola
  • For correspondence: jaana.simola@helsinki.fi satu.palva@helsinki.fi
Felix Siebenhühner
1Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, P.O. Box 21, (Haartmaninkatu 3), FI-00014 Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vladislav Myrov
1Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, P.O. Box 21, (Haartmaninkatu 3), FI-00014 Helsinki, Finland
4Department of Neuroscience and Bioengineering (NBE), Aalto University, 02150 Espoo, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katri Kantojärvi
5Genomics and Biomarkers Unit, Finnish Institute for Health and Welfare, Helsinki, FI-00271 Helsinki, Finland
6Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, FI-00014 Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tiina Paunio
5Genomics and Biomarkers Unit, Finnish Institute for Health and Welfare, Helsinki, FI-00271 Helsinki, Finland
6Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, FI-00014 Helsinki, Finland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Matias Palva
1Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, P.O. Box 21, (Haartmaninkatu 3), FI-00014 Helsinki, Finland
4Department of Neuroscience and Bioengineering (NBE), Aalto University, 02150 Espoo, Finland
7Centre for Cognitive Neuroimaging (CCNi), Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elvira Brattico
8Center for Music in the Brain (MIB), Department of Clinical Medicine, Aarhus University & The Royal Academy of Music Aarhus/Aalborg, 8000 Aarhus C, Denmark
9Department of Education, Psychology, Communication, University of Bari Aldo Moro, 70121 Bari, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Satu Palva
1Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, P.O. Box 21, (Haartmaninkatu 3), FI-00014 Helsinki, Finland
7Centre for Cognitive Neuroimaging (CCNi), Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G12 8QB, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: jaana.simola@helsinki.fi satu.palva@helsinki.fi
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Neuronal oscillations, their inter-areal synchronization and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. However, the genetic underpinnings of oscillatory dynamics have remained poorly understood. We recorded resting-state magnetoencephalography (MEG) from 82 participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in Catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Brain criticality framework and computational modelling of near-critical synchronization dynamics suggested that COMT and BDNF polymorphisms influenced local oscillations via differences in net excitation-inhibition balance. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in local and large-scale synchronization dynamics of neuronal oscillations.

Competing Interest Statement

The authors have declared no competing interest.

  • Abbreviations

    5-HT
    5-hydroxytryptamine
    DA
    dopamine
    DAN
    Dorsal attention network
    DMN
    Default Mode network
    FPN
    Frontoparietal network
    Lim
    Limbic system
    NE
    noradrenaline
    SM
    Somatomotor network
    VAN
    Ventral attention network
    Vis
    Visual network
  • Copyright 
    The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
    Back to top
    PreviousNext
    Posted November 19, 2021.
    Download PDF
    Email

    Thank you for your interest in spreading the word about bioRxiv.

    NOTE: Your email address is requested solely to identify you as the sender of this article.

    Enter multiple addresses on separate lines or separate them with commas.
    Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
    (Your Name) has forwarded a page to you from bioRxiv
    (Your Name) thought you would like to see this page from the bioRxiv website.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Share
    Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
    Jaana Simola, Felix Siebenhühner, Vladislav Myrov, Katri Kantojärvi, Tiina Paunio, J. Matias Palva, Elvira Brattico, Satu Palva
    bioRxiv 2021.11.16.468778; doi: https://doi.org/10.1101/2021.11.16.468778
    Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
    Citation Tools
    Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
    Jaana Simola, Felix Siebenhühner, Vladislav Myrov, Katri Kantojärvi, Tiina Paunio, J. Matias Palva, Elvira Brattico, Satu Palva
    bioRxiv 2021.11.16.468778; doi: https://doi.org/10.1101/2021.11.16.468778

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Subject Area

    • Neuroscience
    Subject Areas
    All Articles
    • Animal Behavior and Cognition (3506)
    • Biochemistry (7348)
    • Bioengineering (5324)
    • Bioinformatics (20266)
    • Biophysics (10020)
    • Cancer Biology (7744)
    • Cell Biology (11306)
    • Clinical Trials (138)
    • Developmental Biology (6437)
    • Ecology (9954)
    • Epidemiology (2065)
    • Evolutionary Biology (13325)
    • Genetics (9361)
    • Genomics (12587)
    • Immunology (7702)
    • Microbiology (19027)
    • Molecular Biology (7444)
    • Neuroscience (41049)
    • Paleontology (300)
    • Pathology (1230)
    • Pharmacology and Toxicology (2138)
    • Physiology (3161)
    • Plant Biology (6861)
    • Scientific Communication and Education (1273)
    • Synthetic Biology (1897)
    • Systems Biology (5313)
    • Zoology (1089)