Recapitulation of patient-specific 3D chromatin conformation using machine learning and validation of identified enhancer-gene targets

Duo Xu; Andre Neil Forbes; Sandra Cohen; Ann Palladino; Tatiana Karadimitriou; Ekta Khurana

doi:10.1101/2021.11.16.468857

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Recapitulation of patient-specific 3D chromatin conformation using machine learning and validation of identified enhancer-gene targets

View ORCID ProfileDuo Xu, Andre Neil Forbes, Sandra Cohen, Ann Palladino, Tatiana Karadimitriou, Ekta Khurana

doi: https://doi.org/10.1101/2021.11.16.468857

Duo Xu

1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

2Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, USA

3Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, USA

4Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA

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ORCID record for Duo Xu

Andre Neil Forbes

1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

2Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, USA

5Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, New York, USA

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Sandra Cohen

1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

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Ann Palladino

1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

2Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, USA

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Tatiana Karadimitriou

1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

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Ekta Khurana

1Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA

2Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, USA

3Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, USA

4Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA

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For correspondence: ekk2003@med.cornell.edu

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Posted November 19, 2021.

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Recapitulation of patient-specific 3D chromatin conformation using machine learning and validation of identified enhancer-gene targets

Duo Xu, Andre Neil Forbes, Sandra Cohen, Ann Palladino, Tatiana Karadimitriou, Ekta Khurana

bioRxiv 2021.11.16.468857; doi: https://doi.org/10.1101/2021.11.16.468857

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Recapitulation of patient-specific 3D chromatin conformation using machine learning and validation of identified enhancer-gene targets

Duo Xu, Andre Neil Forbes, Sandra Cohen, Ann Palladino, Tatiana Karadimitriou, Ekta Khurana

bioRxiv 2021.11.16.468857; doi: https://doi.org/10.1101/2021.11.16.468857

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