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Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice

Woohyun Kim, View ORCID ProfileYoung Woo Noh, Seungjoon Lee, Woochul Choi, View ORCID ProfileSe-Bum Paik, View ORCID ProfileMin Whan Jung, Eunee Lee, View ORCID ProfileEunjoon Kim
doi: https://doi.org/10.1101/2021.11.17.468945
Woohyun Kim
1Department of Biological Sciences, KAIST, Daejeon 34141, Korea
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Young Woo Noh
1Department of Biological Sciences, KAIST, Daejeon 34141, Korea
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Seungjoon Lee
1Department of Biological Sciences, KAIST, Daejeon 34141, Korea
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Woochul Choi
2Department of Bio and Brain Engineering, KAIST, Daejeon 34141, Korea
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Se-Bum Paik
2Department of Bio and Brain Engineering, KAIST, Daejeon 34141, Korea
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Min Whan Jung
1Department of Biological Sciences, KAIST, Daejeon 34141, Korea
3Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 34141, Korea
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  • For correspondence: kime@kaist.ac.kr
Eunee Lee
3Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 34141, Korea
4Department of Anatomy, College of Medicine, Yonsei University, Seoul
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  • For correspondence: kime@kaist.ac.kr
Eunjoon Kim
1Department of Biological Sciences, KAIST, Daejeon 34141, Korea
3Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon 34141, Korea
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  • For correspondence: kime@kaist.ac.kr
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Abstract

Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) of IRSp53-mutant mice, which show social deficits, during social approach. IRSp53-mutant excitatory mPFC neurons displayed an increase in baseline neuronal firing and decreases in variability and dynamic range of firing rates and burst firing during social and non-social target approaches compared to wild-type controls. As a consequence, their firing activity was less differential between social and non-social targets. In addition, there was a decrease in the proportion of excitatory mPFC neurons encoding social information but not that of those encoding non-social information. These results suggest that insufficient neuronal activity dynamics may underlie impaired cortical encoding of social information and social behaviors in IRSp53-mutant mice.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Competing interests: Eunjoon Kim: Reviewing editor, eLife

  • Data Availability: Source Data files have been provided for all figures (except for Figure 1 - figure supplement 1). N/A

  • Ethics: Human Subjects: No Animal Subjects: Yes Ethics Statement: Mice were maintained according to the Animal Research Requirements of Korea Advanced Institute of Science and Technology (KAIST). All experiments were conducted with approval from the Committee on Animal Research at KAIST (approval number KA2020-94).

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Posted November 19, 2021.
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Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice
Woohyun Kim, Young Woo Noh, Seungjoon Lee, Woochul Choi, Se-Bum Paik, Min Whan Jung, Eunee Lee, Eunjoon Kim
bioRxiv 2021.11.17.468945; doi: https://doi.org/10.1101/2021.11.17.468945
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Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice
Woohyun Kim, Young Woo Noh, Seungjoon Lee, Woochul Choi, Se-Bum Paik, Min Whan Jung, Eunee Lee, Eunjoon Kim
bioRxiv 2021.11.17.468945; doi: https://doi.org/10.1101/2021.11.17.468945

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