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Systems medicine dissection of chromosome 1q amplification reveals oncogenic regulatory circuits and informs targeted therapy in cancer
Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Yao-An Shen, View ORCID ProfileIoannis V Kostopoulos, Bien Bergonia, Keren Keren, Paudel Reema, Xiaolin Xiao, Richard M Szydlo, Pierangela MR Sabbattini, Irene AG Roberts, Holger W Auner, Kikkeri N Naresh, Aristeidis Chaidos, Tian-Li Wang, View ORCID ProfileLuca Magnani, Valentina S Caputo, Anastasios Karadimitris
doi: https://doi.org/10.1101/2021.11.17.469031
Nikolaos Trasanidis
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
Alexia Katsarou
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
2Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Foundation Trust, London, United Kingdom
Kanagaraju Ponnusamy
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
Yao-An Shen
3Departments of Pathology, Oncology and Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
4Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
5Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Ioannis V Kostopoulos
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
6Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens, Greece
Bien Bergonia
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
Keren Keren
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
Paudel Reema
7Imperial Experimental Cancer Medicine Centre and Cancer Research UK Imperial Centre, London, United Kingdom
Xiaolin Xiao
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
Richard M Szydlo
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
Pierangela MR Sabbattini
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
Irene AG Roberts
8Department of Paediatrics and MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford University and BRC Blood Theme, NIHR Oxford Biomedical Centre, Oxford, UK
Holger W Auner
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
2Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Foundation Trust, London, United Kingdom
Kikkeri N Naresh
2Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Foundation Trust, London, United Kingdom
7Imperial Experimental Cancer Medicine Centre and Cancer Research UK Imperial Centre, London, United Kingdom
Aristeidis Chaidos
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
2Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Foundation Trust, London, United Kingdom
Tian-Li Wang
3Departments of Pathology, Oncology and Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
4Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Luca Magnani
9Department of Surgery and Cancer, Imperial College London, London, United Kingdom
Valentina S Caputo
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
10Cancer Biology and Therapy laboratory, School of Applied Science, London South Bank University, London, UK
Anastasios Karadimitris
1Hugh & Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
2Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Foundation Trust, London, United Kingdom
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Posted November 20, 2021.
Systems medicine dissection of chromosome 1q amplification reveals oncogenic regulatory circuits and informs targeted therapy in cancer
Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Yao-An Shen, Ioannis V Kostopoulos, Bien Bergonia, Keren Keren, Paudel Reema, Xiaolin Xiao, Richard M Szydlo, Pierangela MR Sabbattini, Irene AG Roberts, Holger W Auner, Kikkeri N Naresh, Aristeidis Chaidos, Tian-Li Wang, Luca Magnani, Valentina S Caputo, Anastasios Karadimitris
bioRxiv 2021.11.17.469031; doi: https://doi.org/10.1101/2021.11.17.469031
Systems medicine dissection of chromosome 1q amplification reveals oncogenic regulatory circuits and informs targeted therapy in cancer
Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Yao-An Shen, Ioannis V Kostopoulos, Bien Bergonia, Keren Keren, Paudel Reema, Xiaolin Xiao, Richard M Szydlo, Pierangela MR Sabbattini, Irene AG Roberts, Holger W Auner, Kikkeri N Naresh, Aristeidis Chaidos, Tian-Li Wang, Luca Magnani, Valentina S Caputo, Anastasios Karadimitris
bioRxiv 2021.11.17.469031; doi: https://doi.org/10.1101/2021.11.17.469031
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