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Awake ripples enhance emotional memory encoding in the human brain

Haoxin Zhang, Ivan Skelin, Shiting Ma, Michelle Paff, Michael A. Yassa, Robert T. Knight, Jack J. Lin
doi: https://doi.org/10.1101/2021.11.17.469047
Haoxin Zhang
1Department of Neurology, University of California Irvine, Irvine, 92603, CA, USA
2Department of Biomedical Engineering, University of California Irvine, Irvine, 92603, CA, USA
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  • For correspondence: haoxinz1@uci.edu linjj@hs.uci.edu
Ivan Skelin
1Department of Neurology, University of California Irvine, Irvine, 92603, CA, USA
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Shiting Ma
1Department of Neurology, University of California Irvine, Irvine, 92603, CA, USA
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Michelle Paff
3Department of Neurosurgery, University of California Irvine, Irvine, 92603, CA, USA
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Michael A. Yassa
1Department of Neurology, University of California Irvine, Irvine, 92603, CA, USA
4Department of Neurobiology and Behavior, University of California Irvine, Irvine, 92603, CA, USA
5Department of Psychological Science, University of California Irvine, Irvine, 92603, CA, USA
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Robert T. Knight
6Department of Psychology, University of California Berkeley, 130 Barker Hall, Berkeley, 94720, CA, USA
7Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, 94720, CA, USA
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Jack J. Lin
1Department of Neurology, University of California Irvine, Irvine, 92603, CA, USA
2Department of Biomedical Engineering, University of California Irvine, Irvine, 92603, CA, USA
8Department of Anatomy and Neurobiology, University of California Irvine, Irvine, 92603, CA, USA
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  • For correspondence: haoxinz1@uci.edu linjj@hs.uci.edu
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Abstract

Intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task reveal increased awake sharp-wave/ripples (aSWR) after encoding of emotional compared to neutral stimuli. Further, post-encoding aSWR-locked memory reinstatement in the amygdala and the hippocampus was predictive of later memory discrimination. These findings provide electrophysiological evidence that post-encoding aSWRs enhance memory for emotional events.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted November 22, 2021.
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Awake ripples enhance emotional memory encoding in the human brain
Haoxin Zhang, Ivan Skelin, Shiting Ma, Michelle Paff, Michael A. Yassa, Robert T. Knight, Jack J. Lin
bioRxiv 2021.11.17.469047; doi: https://doi.org/10.1101/2021.11.17.469047
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Awake ripples enhance emotional memory encoding in the human brain
Haoxin Zhang, Ivan Skelin, Shiting Ma, Michelle Paff, Michael A. Yassa, Robert T. Knight, Jack J. Lin
bioRxiv 2021.11.17.469047; doi: https://doi.org/10.1101/2021.11.17.469047

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