TK216 targets microtubules in Ewing sarcoma cells

New Results

View ORCID ProfileJuan Manuel Povedano, Vicky Li, Katherine E. Lake, Xin Bai, View ORCID ProfileRameshu Rallabandi, Jiwoong Kim, Yang Xie, View ORCID ProfileJef K. De Brabander, View ORCID ProfileDavid G. McFadden

doi: https://doi.org/10.1101/2021.11.19.469182

Juan Manuel Povedano

aDepartment of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

bDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Vicky Li

aDepartment of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

bDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Katherine E. Lake

aDepartment of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

bDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Xin Bai

aDepartment of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

bDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Rameshu Rallabandi

bDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

cHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

dProgram in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Jiwoong Kim

eDepartment of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Yang Xie

eDepartment of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Jef K. De Brabander

bDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

cHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

dProgram in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

David G. McFadden

aDepartment of Internal Medicine, Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

bDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

cHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

dProgram in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA

Supplemental Table_TK216-resistant clones_Somatic Mutations[supplements/469182_file03.xlsx]
HPLC Purity data of YK-4-279, TK216 and enantiomers[supplements/469182_file04.pdf]