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Beamforming seizures from the temporal lobe

Luis Garcia Dominguez, Apameh Tarazi, View ORCID ProfileTaufik Valiante, View ORCID ProfileRichard Wennberg
doi: https://doi.org/10.1101/2021.11.19.469291
Luis Garcia Dominguez
1From the Mitchell Goldhar Magnetoencephalography Unit, Division of Neurology, Krembil Brain Institute, University of Toronto, University Health Network, Toronto Western Hospital, Toronto, Canada
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  • For correspondence: luis.garciadominguez@uhn.ca
Apameh Tarazi
1From the Mitchell Goldhar Magnetoencephalography Unit, Division of Neurology, Krembil Brain Institute, University of Toronto, University Health Network, Toronto Western Hospital, Toronto, Canada
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Taufik Valiante
2Division of Neurosurgery, Krembil Brain Institute, University of Toronto, University Health Network, Toronto Western Hospital, Toronto, Canada
3Center for Advancing Neurotechnological Innovation to Application (CRANIA), University of Toronto, Toronto, Canada
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Richard Wennberg
1From the Mitchell Goldhar Magnetoencephalography Unit, Division of Neurology, Krembil Brain Institute, University of Toronto, University Health Network, Toronto Western Hospital, Toronto, Canada
3Center for Advancing Neurotechnological Innovation to Application (CRANIA), University of Toronto, Toronto, Canada
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  • ORCID record for Richard Wennberg
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Abstract

Background Surgical treatment of drug-resistant temporal lobe epilepsy (TLE) depends on proper identification of the seizure onset zone (SOZ), and differentiation of mesial, temporolimbic seizure onsets from temporal neocortical seizure onsets. Non-invasive source imaging using electroencephalography (EEG) and magnetoencephalography (MEG) can provide accurate information on interictal spike localization; however, EEG and MEG have low sensitivity for epileptiform activity restricted to deep temporolimbic structures. Moreover, in mesial temporal lobe epilepsy (MTLE), interictal spikes frequently arise in neocortical foci distant from the SOZ, rendering interictal spike localization potentially misleading for presurgical planning.

Methods In this study, we used two different beamformer techniques applied to the MEG signal of ictal events acquired during EEG-MEG recordings in six patients with TLE (three neocortical, three MTLE). The ictal source localization results were compared to the patients’ ground truth SOZ localizations determined from intracranial EEG and/or clinical, neuroimaging and postsurgical outcome evidence.

Results Beamformer analysis proved to be highly accurate in all cases and able to reliably identify focal seizure onsets localized to mesial, temporolimbic structures. In three patients, interictal spikes were either absent, too complex for inverse dipole modeling, or localized to anterolateral temporal neocortex distant to a mesial temporal SOZ.

Conclusions This report demonstrates the suitability of MEG beamformer analysis of ictal events in TLE, which can supersede or complement the traditional analysis of interictal spikes. The method outlined is applicable to any type of epileptiform event, greatly expanding the information value of MEG and broadening its utility for presurgical recording in epilepsy.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 24, 2021.
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Beamforming seizures from the temporal lobe
Luis Garcia Dominguez, Apameh Tarazi, Taufik Valiante, Richard Wennberg
bioRxiv 2021.11.19.469291; doi: https://doi.org/10.1101/2021.11.19.469291
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Beamforming seizures from the temporal lobe
Luis Garcia Dominguez, Apameh Tarazi, Taufik Valiante, Richard Wennberg
bioRxiv 2021.11.19.469291; doi: https://doi.org/10.1101/2021.11.19.469291

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