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Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy
Stefan Naulaerts, Daniel M Borras, Asier Antoranz Martinez, Julie Messiaen, Yannick Van Herck, Lendert Gelens, Tom Venken, Isaure Vanmeerbeek, Sanket More, Jenny Sprooten, Oliver Bechter, Gabriele Bergers, Adrian Liston, Steven De Vleeschouwer, Benoit J Van Den Eynde, Diether Lambrechts, Jannie Borst, Francesca Bosisio, Sabine Tejpar, Frederik De Smet, Abhishek D Garg
doi: https://doi.org/10.1101/2021.11.22.468617
Stefan Naulaerts
1Ludwig Institute for Cancer Research, Brussels, Belgium
2De Duve Institute, UC Louvain, Brussels, Belgium
Daniel M Borras
3Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Belgium
Asier Antoranz Martinez
4Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research, Department of Imaging & Pathology, KU Leuven, Belgium
Julie Messiaen
4Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research, Department of Imaging & Pathology, KU Leuven, Belgium
Yannick Van Herck
5Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Belgium
Lendert Gelens
6Laboratory of Dynamics in Biological Systems, Department of Cellular & Molecular Medicine, KU Leuven, Belgium
Tom Venken
7Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Belgium
8VIB Center for Cancer Biology, VIB, Leuven, Belgium
Isaure Vanmeerbeek
3Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Belgium
Sanket More
9Laboratory of Cell Death Research & Therapy, Department of Cellular & Molecular Medicine, KU Leuven, Belgium
Jenny Sprooten
3Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Belgium
Oliver Bechter
5Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Belgium
Gabriele Bergers
10Laboratory of Tumor Microenvironment and Therapeutic Resistance, Department of Oncology, VIB-Center for Cancer Biology, KU Leuven, Leuven, Belgium
11Department of Neurological Surgery, UCSF Comprehensive Cancer Center, UCSF, San Francisco, CA, United States
Adrian Liston
12VIB Center for Brain and Disease Research, Leuven, Belgium
13Department of Microbiology and Immunology, KU Leuven, Belgium
14Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK
Steven De Vleeschouwer
15Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium
16Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Belgium
17Leuven Brain Institute (LBI), Leuven, Belgium
Benoit J Van Den Eynde
1Ludwig Institute for Cancer Research, Brussels, Belgium
2De Duve Institute, UC Louvain, Brussels, Belgium
Diether Lambrechts
7Laboratory of Translational Genetics, Department of Human Genetics, KU Leuven, Belgium
8VIB Center for Cancer Biology, VIB, Leuven, Belgium
Jannie Borst
18Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, Netherlands
Francesca Bosisio
19Translational Cell & Tissue Research, Department of Imaging & Pathology, KU Leuven, Belgium
Sabine Tejpar
20Laboratory for Molecular Digestive Oncology, Department of Oncology, KU Leuven, Belgium
Frederik De Smet
4Laboratory for Precision Cancer Medicine, Translational Cell and Tissue Research, Department of Imaging & Pathology, KU Leuven, Belgium
Abhishek D Garg
3Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Belgium
Posted November 22, 2021.
Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy
Stefan Naulaerts, Daniel M Borras, Asier Antoranz Martinez, Julie Messiaen, Yannick Van Herck, Lendert Gelens, Tom Venken, Isaure Vanmeerbeek, Sanket More, Jenny Sprooten, Oliver Bechter, Gabriele Bergers, Adrian Liston, Steven De Vleeschouwer, Benoit J Van Den Eynde, Diether Lambrechts, Jannie Borst, Francesca Bosisio, Sabine Tejpar, Frederik De Smet, Abhishek D Garg
bioRxiv 2021.11.22.468617; doi: https://doi.org/10.1101/2021.11.22.468617
Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy
Stefan Naulaerts, Daniel M Borras, Asier Antoranz Martinez, Julie Messiaen, Yannick Van Herck, Lendert Gelens, Tom Venken, Isaure Vanmeerbeek, Sanket More, Jenny Sprooten, Oliver Bechter, Gabriele Bergers, Adrian Liston, Steven De Vleeschouwer, Benoit J Van Den Eynde, Diether Lambrechts, Jannie Borst, Francesca Bosisio, Sabine Tejpar, Frederik De Smet, Abhishek D Garg
bioRxiv 2021.11.22.468617; doi: https://doi.org/10.1101/2021.11.22.468617
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