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The Unique Cytoarchitecture and Wiring of the Human Default Mode Network

View ORCID ProfileCasey Paquola, Margaret Garber, Stefan Frässle, Jessica Royer, Shahin Tavakol, Raul Rodriguez-Cruces, Elizabeth Jeffries, Jonathan Smallwood, View ORCID ProfileBoris Bernhardt
doi: https://doi.org/10.1101/2021.11.22.469533
Casey Paquola
1Montreal Neurological Institute & Hospital, McGill University, Montréal, Quebec, Canada
2INM-1, Forschungszentrum Jülich, Jülich, Germany
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  • For correspondence: casey.paquola@gmail.com
Margaret Garber
1Montreal Neurological Institute & Hospital, McGill University, Montréal, Quebec, Canada
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Stefan Frässle
3Translational Neuromodeling Unit (TNU), University of Zurich & ETH Zurich, Zurich, Switzerland
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Jessica Royer
1Montreal Neurological Institute & Hospital, McGill University, Montréal, Quebec, Canada
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Shahin Tavakol
1Montreal Neurological Institute & Hospital, McGill University, Montréal, Quebec, Canada
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Raul Rodriguez-Cruces
1Montreal Neurological Institute & Hospital, McGill University, Montréal, Quebec, Canada
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Elizabeth Jeffries
4Department of Psychology, University of York, York, York, United Kingdom
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Jonathan Smallwood
5Department of Psychology, Queen’s University, Kingston, Ontario, Canada
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Boris Bernhardt
1Montreal Neurological Institute & Hospital, McGill University, Montréal, Quebec, Canada
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ABSTRACT

It is challenging to specify the role of the default mode network (DMN) in human behaviour. Contemporary theories, based on functional magnetic resonance imaging (MRI), suggest that the DMN is insulated from the external world, which allows it to support perceptually-decoupled states and to integrate external and internal information in the construction of abstract meanings. To date, the neuronal architecture of the DMN has received relatively little attention. Understanding the cytoarchitectural composition and connectional layout of the DMN will provide novel insights into its role in brain function. We mapped cytoarchitectural variation within the DMN using a cortical type atlas and a histological model of the entire human brain. Next, we used MRI acquired in healthy young adults to explicate structural wiring and effective connectivity. We discovered profound diversity of DMN cytoarchitecture. Connectivity is organised along the most dominant cytoarchitectural axis. One side of the axis is the prominent receiver, whereas the other side remains more insulated, especially from sensory areas. The structural heterogeneity of the DMN engenders a network-level balance in communication with external and internal sources, which is distinctive, relative to other functional communities. The neuronal architecture of the DMN suggests it is a protuberance from the core cortical processing hierarchy and holds a unique role in information integration.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 22, 2021.
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The Unique Cytoarchitecture and Wiring of the Human Default Mode Network
Casey Paquola, Margaret Garber, Stefan Frässle, Jessica Royer, Shahin Tavakol, Raul Rodriguez-Cruces, Elizabeth Jeffries, Jonathan Smallwood, Boris Bernhardt
bioRxiv 2021.11.22.469533; doi: https://doi.org/10.1101/2021.11.22.469533
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The Unique Cytoarchitecture and Wiring of the Human Default Mode Network
Casey Paquola, Margaret Garber, Stefan Frässle, Jessica Royer, Shahin Tavakol, Raul Rodriguez-Cruces, Elizabeth Jeffries, Jonathan Smallwood, Boris Bernhardt
bioRxiv 2021.11.22.469533; doi: https://doi.org/10.1101/2021.11.22.469533

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