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Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in mediating targeted therapy dosage challenges
Kai Song, Jenna K. Minami, William P. Crosson, Jesus Salazar, Eli Pazol, Niroshi T. Senaratne, Nagesh Rao, Kim Paraiso, Thomas G. Graeber
doi: https://doi.org/10.1101/2021.11.23.468420
Kai Song
1Department of Bioengineering, UCLA, Los Angeles, CA 90095, USA
Jenna K. Minami
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
3Department of Integrative Biology and Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
William P. Crosson
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Jesus Salazar
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Eli Pazol
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Niroshi T. Senaratne
8Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Nagesh Rao
8Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Kim Paraiso
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Thomas G. Graeber
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
4Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
5Crump Institute for Molecular Imaging, UCLA, Los Angeles, CA 90095, USA
6California NanoSystems Institute, UCLA, Los Angeles, CA 90095, USA
7Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA 90095, USA
Article usage
Posted November 24, 2021.
Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in mediating targeted therapy dosage challenges
Kai Song, Jenna K. Minami, William P. Crosson, Jesus Salazar, Eli Pazol, Niroshi T. Senaratne, Nagesh Rao, Kim Paraiso, Thomas G. Graeber
bioRxiv 2021.11.23.468420; doi: https://doi.org/10.1101/2021.11.23.468420
Plasticity of extrachromosomal and intrachromosomal BRAF amplifications in mediating targeted therapy dosage challenges
Kai Song, Jenna K. Minami, William P. Crosson, Jesus Salazar, Eli Pazol, Niroshi T. Senaratne, Nagesh Rao, Kim Paraiso, Thomas G. Graeber
bioRxiv 2021.11.23.468420; doi: https://doi.org/10.1101/2021.11.23.468420
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