Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
Confirmatory Results

Best practices for design and fabrication of biomicrofluidic devices by resin 3D printing

View ORCID ProfileHannah B. Musgrove, View ORCID ProfileMegan A. Catterton, View ORCID ProfileRebecca R. Pompano
doi: https://doi.org/10.1101/2021.11.23.468853
Hannah B. Musgrove
Department of Chemistry, University of Virginia. Charlottesville, VA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Hannah B. Musgrove
Megan A. Catterton
Department of Chemistry, University of Virginia. Charlottesville, VA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Megan A. Catterton
Rebecca R. Pompano
Department of Chemistry, University of Virginia. Charlottesville, VA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Rebecca R. Pompano
  • For correspondence: rrp2z@virginia.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

Stereolithographic (SL) 3D printing, especially digital light processing (DLP) printing, is a promising rapid fabrication method for bio-microfluidic applications such as clinical tests, lab-on-a-chip devices, and sensor integrated devices. The benefits of 3D printing lead many to believe this fabrication method will accelerate the use of bioanalytical microfluidics, but there are major obstacles to overcome to fully utilize this technology. For commercially available printing materials, this includes challenges in producing prints with the print resolution and mechanical stability required for a particular design, along with cytotoxic components within many SL resins and low optical compatibility for imaging experiments. Potential solutions to these problems are scattered throughout the literature and rarely available in head-to-head comparisons. Therefore, we present here principles for navigation of 3D printing techniques and systematic tests to inform resin selection and optimization of the design and fabrication of SL 3D printed bio-microfluidic devices.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted November 25, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Best practices for design and fabrication of biomicrofluidic devices by resin 3D printing
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Best practices for design and fabrication of biomicrofluidic devices by resin 3D printing
Hannah B. Musgrove, Megan A. Catterton, Rebecca R. Pompano
bioRxiv 2021.11.23.468853; doi: https://doi.org/10.1101/2021.11.23.468853
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Best practices for design and fabrication of biomicrofluidic devices by resin 3D printing
Hannah B. Musgrove, Megan A. Catterton, Rebecca R. Pompano
bioRxiv 2021.11.23.468853; doi: https://doi.org/10.1101/2021.11.23.468853

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioengineering
Subject Areas
All Articles
  • Animal Behavior and Cognition (4118)
  • Biochemistry (8825)
  • Bioengineering (6529)
  • Bioinformatics (23481)
  • Biophysics (11802)
  • Cancer Biology (9221)
  • Cell Biology (13334)
  • Clinical Trials (138)
  • Developmental Biology (7442)
  • Ecology (11422)
  • Epidemiology (2066)
  • Evolutionary Biology (15169)
  • Genetics (10449)
  • Genomics (14054)
  • Immunology (9184)
  • Microbiology (22186)
  • Molecular Biology (8821)
  • Neuroscience (47615)
  • Paleontology (350)
  • Pathology (1431)
  • Pharmacology and Toxicology (2492)
  • Physiology (3736)
  • Plant Biology (8086)
  • Scientific Communication and Education (1438)
  • Synthetic Biology (2222)
  • Systems Biology (6042)
  • Zoology (1254)