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A target expression threshold dictates invader defense and autoimmunity by CRISPR-Cas13

View ORCID ProfileElena Vialetto, View ORCID ProfileYanying Yu, Scott P. Collins, View ORCID ProfileKatharina G. Wandera, View ORCID ProfileLars Barquist, Chase L. Beisel
doi: https://doi.org/10.1101/2021.11.23.469693
Elena Vialetto
1Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany
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  • ORCID record for Elena Vialetto
Yanying Yu
1Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany
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Scott P. Collins
2Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
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Katharina G. Wandera
1Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany
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  • ORCID record for Katharina G. Wandera
Lars Barquist
1Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany
3Medical Faculty, University of Würzburg, 97080 Würzburg, Germany
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Chase L. Beisel
1Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany
2Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
3Medical Faculty, University of Würzburg, 97080 Würzburg, Germany
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  • For correspondence: chase.beisel@helmholtz-hiri.de
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Article Information

doi 
https://doi.org/10.1101/2021.11.23.469693
History 
  • November 23, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Elena Vialetto1,
  2. Yanying Yu1,
  3. Scott P. Collins2,
  4. Katharina G. Wandera1,
  5. Lars Barquist1,3 and
  6. Chase L. Beisel1,2,3,*
  1. 1Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany
  2. 2Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
  3. 3Medical Faculty, University of Würzburg, 97080 Würzburg, Germany
  1. ↵*Correspondence to: chase.beisel{at}helmholtz-hiri.de (to C.L.B.)
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Posted November 23, 2021.
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A target expression threshold dictates invader defense and autoimmunity by CRISPR-Cas13
Elena Vialetto, Yanying Yu, Scott P. Collins, Katharina G. Wandera, Lars Barquist, Chase L. Beisel
bioRxiv 2021.11.23.469693; doi: https://doi.org/10.1101/2021.11.23.469693
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A target expression threshold dictates invader defense and autoimmunity by CRISPR-Cas13
Elena Vialetto, Yanying Yu, Scott P. Collins, Katharina G. Wandera, Lars Barquist, Chase L. Beisel
bioRxiv 2021.11.23.469693; doi: https://doi.org/10.1101/2021.11.23.469693

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