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Mammalian octopus cells are direction selective to frequency sweeps by synaptic sequence detection

View ORCID ProfileHsin-Wei Lu, View ORCID ProfilePhilip Smith, View ORCID ProfilePhilip Joris
doi: https://doi.org/10.1101/2021.11.29.470040
Hsin-Wei Lu
1Lab of Auditory Neurophysiology, KU Leuven, Leuven, Belgium
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Philip Smith
2Department of Neuroscience, University of Wisconsin, Madison, USA
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Philip Joris
1Lab of Auditory Neurophysiology, KU Leuven, Leuven, Belgium
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  • For correspondence: philip.joris@kuleuven.be
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Summary

Octopus cells are remarkable projection neurons of the mammalian cochlear nucleus, with extremely fast membranes and wide frequency tuning. They are considered prime examples of coincidence detectors but are poorly characterized in vivo. We discover that octopus cells are selective to frequency sweep direction, a feature that is absent in their auditory nerve inputs. In vivo intracellular recordings reveal that direction selectivity does not derive from cross-channel coincidence detection but hinges on the amplitudes and activation sequence of auditory nerve inputs tuned to clusters of “hotspot” frequencies. A simple biophysical model of octopus cell excited with real nerve spike trains recreates direction selectivity through interaction of intrinsic membrane conductances with activation sequence of clustered inputs. We conclude that octopus cells are sequence detectors, sensitive to temporal patterns across cochlear frequency channels. The detection of sequences rather than coincidences is a much simpler but powerful operation to extract temporal information.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 30, 2021.
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Mammalian octopus cells are direction selective to frequency sweeps by synaptic sequence detection
Hsin-Wei Lu, Philip Smith, Philip Joris
bioRxiv 2021.11.29.470040; doi: https://doi.org/10.1101/2021.11.29.470040
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Mammalian octopus cells are direction selective to frequency sweeps by synaptic sequence detection
Hsin-Wei Lu, Philip Smith, Philip Joris
bioRxiv 2021.11.29.470040; doi: https://doi.org/10.1101/2021.11.29.470040

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