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A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Xiaofei Wang, Ao Hu, Xiangyu Chen, Yixin Zhang, Fei Yu, Shuai Yue, Arong Li, Junsong Zhang, Zhiwei Pan, Yang Yang, Yao Lin, Leiqiong Gao, Jing Zhou, Jing Zhao, Fang Li, Yaling Shi, Feng Huang, Xiaofan Yang, Yi Peng, Luoyang Tu, Huan Zhang, Huanying Zheng, Jun He, Hui Zhang, Lifan Xu, QizhAo Huang, Yongqun Zhu, Kai Deng, Lilin Ye
doi: https://doi.org/10.1101/2021.11.29.470356
Xiaofei Wang
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
2Department of Gastroenterology of the Second Affiliated Hospital School of Medicine, and Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China
3The MOE Key Laboratory for Biosystems Homeostasis & Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China
Ao Hu
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Xiangyu Chen
4School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China
5Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing 400038, China
Yixin Zhang
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Fei Yu
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
6Medical Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
Shuai Yue
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
Arong Li
2Department of Gastroenterology of the Second Affiliated Hospital School of Medicine, and Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China
3The MOE Key Laboratory for Biosystems Homeostasis & Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China
Junsong Zhang
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
6Medical Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
Zhiwei Pan
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
Yang Yang
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
Yao Lin
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
Leiqiong Gao
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
Jing Zhou
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
Jing Zhao
8Biomedical Analysis Center, Third Military Medical University, Chongqing, China
Fang Li
9Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
10Guangzhou Women and Children Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China
Yaling Shi
9Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China
Feng Huang
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
6Medical Research Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
Xiaofan Yang
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Yi Peng
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Luoyang Tu
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Huan Zhang
11Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China
Huanying Zheng
11Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, China
Jun He
12Center for Cell Lineage and Development, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong, China
Hui Zhang
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Lifan Xu
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
QizhAo Huang
4School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China
Yongqun Zhu
2Department of Gastroenterology of the Second Affiliated Hospital School of Medicine, and Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China
3The MOE Key Laboratory for Biosystems Homeostasis & Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China
Kai Deng
1Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
Lilin Ye
7Institute of Immunology, PLA, Third Military Medical University, Chongqing, China
Article usage
Posted January 13, 2022.
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Xiaofei Wang, Ao Hu, Xiangyu Chen, Yixin Zhang, Fei Yu, Shuai Yue, Arong Li, Junsong Zhang, Zhiwei Pan, Yang Yang, Yao Lin, Leiqiong Gao, Jing Zhou, Jing Zhao, Fang Li, Yaling Shi, Feng Huang, Xiaofan Yang, Yi Peng, Luoyang Tu, Huan Zhang, Huanying Zheng, Jun He, Hui Zhang, Lifan Xu, QizhAo Huang, Yongqun Zhu, Kai Deng, Lilin Ye
bioRxiv 2021.11.29.470356; doi: https://doi.org/10.1101/2021.11.29.470356
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Xiaofei Wang, Ao Hu, Xiangyu Chen, Yixin Zhang, Fei Yu, Shuai Yue, Arong Li, Junsong Zhang, Zhiwei Pan, Yang Yang, Yao Lin, Leiqiong Gao, Jing Zhou, Jing Zhao, Fang Li, Yaling Shi, Feng Huang, Xiaofan Yang, Yi Peng, Luoyang Tu, Huan Zhang, Huanying Zheng, Jun He, Hui Zhang, Lifan Xu, QizhAo Huang, Yongqun Zhu, Kai Deng, Lilin Ye
bioRxiv 2021.11.29.470356; doi: https://doi.org/10.1101/2021.11.29.470356
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