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Transposon Extermination Reveals Their Adaptive Fitness Contribution

Susanne Cranz-Mileva, Eve Reilly, Noor Chalhoub, Rohan Patel, Tania Atanassova, Weihuan Cao, Christopher Ellison, View ORCID ProfileMikel Zaratiegui
doi: https://doi.org/10.1101/2021.11.29.470382
Susanne Cranz-Mileva
1Department of Molecular Biology and Biochemistry, the State University of New Jersey, Piscataway, NJ, USA
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Eve Reilly
1Department of Molecular Biology and Biochemistry, the State University of New Jersey, Piscataway, NJ, USA
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Noor Chalhoub
1Department of Molecular Biology and Biochemistry, the State University of New Jersey, Piscataway, NJ, USA
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Rohan Patel
1Department of Molecular Biology and Biochemistry, the State University of New Jersey, Piscataway, NJ, USA
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Tania Atanassova
1Department of Molecular Biology and Biochemistry, the State University of New Jersey, Piscataway, NJ, USA
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Weihuan Cao
2Department of Genetics, Rutgers, the State University of New Jersey, Piscataway, NJ, USA
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Christopher Ellison
2Department of Genetics, Rutgers, the State University of New Jersey, Piscataway, NJ, USA
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Mikel Zaratiegui
1Department of Molecular Biology and Biochemistry, the State University of New Jersey, Piscataway, NJ, USA
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  • ORCID record for Mikel Zaratiegui
  • For correspondence: zaratiegui@dls.rutgers.edu
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Abstract

Transposable Elements are molecular parasites that persist in their host genome by generating new copies to outpace natural selection. Here we measure the parameters governing the copy number dynamics of the fission yeast Tf2 retrotransposons, using experimental and natural populations and a strain where all Tf2 copies are removed. Natural population genomes display active and persistent Tf2 colonies, but in the absence of selection mitotic recombination deletes Tf2 elements at rates that far exceed transposition. We show that Tf2 elements provide a fitness contribution to their host by dynamically rewiring the transcriptional response to metabolic stress. Therefore, Tf2 elements exhibit a mutualistic rather than parasitic behavior toward their host.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted November 30, 2021.
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Transposon Extermination Reveals Their Adaptive Fitness Contribution
Susanne Cranz-Mileva, Eve Reilly, Noor Chalhoub, Rohan Patel, Tania Atanassova, Weihuan Cao, Christopher Ellison, Mikel Zaratiegui
bioRxiv 2021.11.29.470382; doi: https://doi.org/10.1101/2021.11.29.470382
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Transposon Extermination Reveals Their Adaptive Fitness Contribution
Susanne Cranz-Mileva, Eve Reilly, Noor Chalhoub, Rohan Patel, Tania Atanassova, Weihuan Cao, Christopher Ellison, Mikel Zaratiegui
bioRxiv 2021.11.29.470382; doi: https://doi.org/10.1101/2021.11.29.470382

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