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OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
View ORCID ProfileGabriel Sturm, View ORCID ProfileKalpita R Karan, View ORCID ProfileAnna Monzel, Balaji S Santhanam, Tanja Taivassalo, Céline Bris, Sarah A Duplaga, Marissa Cross, View ORCID ProfileAtif Towheed, Albert Higgins-Chen, Meagan J McManus, View ORCID ProfileAndres Cardenas, Jue Lin, Elissa S Epel, View ORCID ProfileShamima Rahman, View ORCID ProfileJohn Vissing, Bruno Grassi, View ORCID ProfileMorgan Levine, View ORCID ProfileSteve Horvath, Ronald G Haller, View ORCID ProfileGuy Lenaers, View ORCID ProfileDouglas C Wallace, View ORCID ProfileSaeed Tavazoie, View ORCID ProfileVincent Procaccio, View ORCID ProfileBrett A Kaufman, View ORCID ProfileErin L Seifert, View ORCID ProfileMichio Hirano, View ORCID ProfileMartin Picard
doi: https://doi.org/10.1101/2021.11.29.470428
Gabriel Sturm
1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
Kalpita R Karan
1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
Anna Monzel
1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
Balaji S Santhanam
2Departments of Biological Sciences, Systems Biology, and Biochemistry and Molecular Biophysics, Institute for Cancer Dynamics, Columbia University, New York, United States
Tanja Taivassalo
3Department of Physiology and Functional Genomics, Clinical and Translational Research Building, University of Florida, Gainesville, FL, United states
Céline Bris
4Department of Genetics, Angers Hospital, Angers, France
5Angers University, MitoLab team, UMR CNRS 6015 - INSERM U1083, MitoVasc Institute, Angers, France
Sarah A Duplaga
6Department of Medicine, Vascular Medicine Institute and Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Marissa Cross
1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
Atif Towheed
1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
7Touro College of Osteopathic Medicine, Middletown, NY, United States
Albert Higgins-Chen
8Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Meagan J McManus
9Department of Anesthesiology and Critical Care Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States
10Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States
Andres Cardenas
11Department of Environmental Health Sciences and Center for Computational Biology, University of California Berkeley, Berkeley, CA, United States
Jue Lin
12Department of Biochemistry and Biophysics, University of California, San Francisco, CA, United States
Elissa S Epel
13Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, United States
Shamima Rahman
14Mitochondrial Research Group, UCL Great Ormond Street Institute of Child Health, and Metabolic Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
John Vissing
15Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Bruno Grassi
16Department of Medicine, University of Udine, Udine, Italy
Morgan Levine
17Department of Pathology, Yale University School of Medicine, New Haven, CT, United States
Steve Horvath
18Human Genetics, David Geffen School of Medicine, University of California, Los Angeles CA, United States
Ronald G Haller
19Neuromuscular Center, Institute for Exercise and Environmental Medicine of Texas Health Resources and Department of Neurology, University of Texas Southwestern Medical Center, United States
Guy Lenaers
4Department of Genetics, Angers Hospital, Angers, France
5Angers University, MitoLab team, UMR CNRS 6015 - INSERM U1083, MitoVasc Institute, Angers, France
Douglas C Wallace
10Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States
Saeed Tavazoie
2Departments of Biological Sciences, Systems Biology, and Biochemistry and Molecular Biophysics, Institute for Cancer Dynamics, Columbia University, New York, United States
Vincent Procaccio
4Department of Genetics, Angers Hospital, Angers, France
5Angers University, MitoLab team, UMR CNRS 6015 - INSERM U1083, MitoVasc Institute, Angers, France
Brett A Kaufman
6Department of Medicine, Vascular Medicine Institute and Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, United States
Erin L Seifert
21Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology and MitoCare Center, Philadelphia, PA, United States
Michio Hirano
22Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, NY, United States
Martin Picard
1Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York, NY, United States
22Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York, NY, United States
23New York State Psychiatric Institute, New York, NY, United States
Posted November 30, 2021.
OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
Gabriel Sturm, Kalpita R Karan, Anna Monzel, Balaji S Santhanam, Tanja Taivassalo, Céline Bris, Sarah A Duplaga, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J McManus, Andres Cardenas, Jue Lin, Elissa S Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G Haller, Guy Lenaers, Douglas C Wallace, Saeed Tavazoie, Vincent Procaccio, Brett A Kaufman, Erin L Seifert, Michio Hirano, Martin Picard
bioRxiv 2021.11.29.470428; doi: https://doi.org/10.1101/2021.11.29.470428
OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
Gabriel Sturm, Kalpita R Karan, Anna Monzel, Balaji S Santhanam, Tanja Taivassalo, Céline Bris, Sarah A Duplaga, Marissa Cross, Atif Towheed, Albert Higgins-Chen, Meagan J McManus, Andres Cardenas, Jue Lin, Elissa S Epel, Shamima Rahman, John Vissing, Bruno Grassi, Morgan Levine, Steve Horvath, Ronald G Haller, Guy Lenaers, Douglas C Wallace, Saeed Tavazoie, Vincent Procaccio, Brett A Kaufman, Erin L Seifert, Michio Hirano, Martin Picard
bioRxiv 2021.11.29.470428; doi: https://doi.org/10.1101/2021.11.29.470428
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