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TRPA1: A Potential Prognostic Indicator for Oral Squamous Cell Carcinoma

View ORCID ProfileRajdeep Chakraborty, View ORCID ProfileAmara Jabeen, View ORCID ProfileHonghua Hu, View ORCID ProfileCharbel Darido, View ORCID ProfileKaren Vickery, View ORCID ProfileShoba Ranganathan
doi: https://doi.org/10.1101/2021.11.29.470496
Rajdeep Chakraborty
1Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia; (R.C.); (K.V.); (H.H.)
2Applied Biosciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia; (A.J.) (S.R.)
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  • ORCID record for Rajdeep Chakraborty
  • For correspondence: rajdeep.chakraborty@hdr.mq.edu.au karen.vickery@mq.edu.au helen.hu@mq.edu.au amara.jabeen@mq.edu.au shoba.ranganathan@mq.edu.au
Amara Jabeen
2Applied Biosciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia; (A.J.) (S.R.)
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  • ORCID record for Amara Jabeen
  • For correspondence: amara.jabeen@mq.edu.au shoba.ranganathan@mq.edu.au
Honghua Hu
1Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia; (R.C.); (K.V.); (H.H.)
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  • For correspondence: rajdeep.chakraborty@hdr.mq.edu.au karen.vickery@mq.edu.au helen.hu@mq.edu.au
Charbel Darido
3Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; (C.D.)
4Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC 3000, Australia
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  • For correspondence: charbel.darido@petermac.org
Karen Vickery
1Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW 2109, Australia; (R.C.); (K.V.); (H.H.)
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  • For correspondence: rajdeep.chakraborty@hdr.mq.edu.au karen.vickery@mq.edu.au helen.hu@mq.edu.au
Shoba Ranganathan
2Applied Biosciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia; (A.J.) (S.R.)
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  • For correspondence: shoba.ranganathan@mq.edu.au amara.jabeen@mq.edu.au shoba.ranganathan@mq.edu.au
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Abstract

Introduction Transient receptors are related to oral cancer pain. Previously capsaicin (TRPV1 agonist) was shown to induce cell death in oral cancer cells. We hypothesised that these receptors are present in oral cancer.

Method We examined the presence of cannabinoid receptors (CB1 and CB2) and targets (TRPV1, TRPA1, CaV 3.1, CaV 3.2, CaV 3.3) via quantitative polymerase chain reaction (qPCR) in oral cancer cells SCC4, SCC9, SCC25, Cal27, and normal oral cell line OKF6.

Result Cannabinoid receptors are absent in all the cell lines, while TRPA1 is only present in normal cells, but absent in all the oral cancer cell lines. Voltage-gated calcium channels are present in all the cell lines.

Conclusion and Future Aspects TRPA1 could be the possible future prognostic indicator of oral squamous cell carcinoma. Future functionality assays could use precancerous cell lines to follow the loss of TRPA1.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 30, 2021.
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TRPA1: A Potential Prognostic Indicator for Oral Squamous Cell Carcinoma
Rajdeep Chakraborty, Amara Jabeen, Honghua Hu, Charbel Darido, Karen Vickery, Shoba Ranganathan
bioRxiv 2021.11.29.470496; doi: https://doi.org/10.1101/2021.11.29.470496
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TRPA1: A Potential Prognostic Indicator for Oral Squamous Cell Carcinoma
Rajdeep Chakraborty, Amara Jabeen, Honghua Hu, Charbel Darido, Karen Vickery, Shoba Ranganathan
bioRxiv 2021.11.29.470496; doi: https://doi.org/10.1101/2021.11.29.470496

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