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De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma
Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Wenhua Gao, Januka Khanal, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Peter Ly, Nathalie Y. R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin Jr., Samuel K. McBrayer
doi: https://doi.org/10.1101/2021.11.30.470443
Diana D. Shi
1Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02215, USA
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Milan R. Savani
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
3Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Michael M. Levitt
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Adam C. Wang
4Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
Jennifer E. Endress
5Ludwig Cancer Center, Boston, MA 02115, USA
6Harvard Medical School, Boston, MA 02115, USA
Cylaina E. Bird
7Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
Joseph Buehler
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Sylwia A. Stopka
8Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
9Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Michael S. Regan
8Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Yu-Fen Lin
10Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Wenhua Gao
4Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
Januka Khanal
4Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
Min Xu
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Bofu Huang
4Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
Rebecca B. Jennings
4Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
11Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Dennis M. Bonal
12Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA
Misty S. Martin-Sandoval
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Tammie Dang
13Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Lauren C. Gattie
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
7Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
Sungwoo Lee
14New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea
John M. Asara
15Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
16Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Harley I. Kornblum
17Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA 90095, USA
18Department of Psychiatry and Behavioral Sciences, and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA
Tak W. Mak
19The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada
20The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada
21Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada
Ryan E. Looper
22Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA
Quang-De Nguyen
12Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA
Sabina Signoretti
4Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
11Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Stefan Gradl
23Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany
Andreas Sutter
23Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany
Michael Jeffers
24Bayer HealthCare Pharmaceuticals, Inc., Whippany, NJ 07981, USA
Andreas Janzer
23Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany
Mark A. Lehrman
13Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Lauren G. Zacharias
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Thomas P. Mathews
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Timothy E. Richardson
25Department of Pathology, Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX 75229, USA
Daniel P. Cahill
26Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
Ralph J. DeBerardinis
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
27Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
28Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
29Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
Keith L. Ligon
11Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
30Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
31Department of Pathology, Children’s Hospital Boston, Boston, MA 02115, USA
Peter Ly
10Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Nathalie Y. R. Agar
8Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
9Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
32Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
Kalil G. Abdullah
7Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
29Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
33Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
Isaac S. Harris
34Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA
William G. Kaelin Jr.
4Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA
27Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
Samuel K. McBrayer
2Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
28Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
29Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
Article usage
Posted December 01, 2021.
De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma
Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Wenhua Gao, Januka Khanal, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Peter Ly, Nathalie Y. R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin Jr., Samuel K. McBrayer
bioRxiv 2021.11.30.470443; doi: https://doi.org/10.1101/2021.11.30.470443
De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma
Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Wenhua Gao, Januka Khanal, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Peter Ly, Nathalie Y. R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin Jr., Samuel K. McBrayer
bioRxiv 2021.11.30.470443; doi: https://doi.org/10.1101/2021.11.30.470443
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