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Induction of mitochondrial heat shock proteins and mitochondrial biogenesis in endothelial cells upon acute methylglyoxal stress: Evidence for hormetic autofeedback

Ruben Bulkescher, Thomas Fleming, Claus Rodemer, Rebekka Medert, Marc Freichel, Matthias Mayer, Julia Szendroedi, Stephan Herzig, View ORCID ProfileJohanna Zemva
doi: https://doi.org/10.1101/2021.11.30.470545
Ruben Bulkescher
1Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
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Thomas Fleming
1Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
2German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany
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Claus Rodemer
1Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
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Rebekka Medert
3Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
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Marc Freichel
3Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
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Matthias Mayer
4Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany
5DKFZ-ZMBH Alliance, Heidelberg, Germany
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Julia Szendroedi
1Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
2German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany
6Joint Heidelberg-IDC Translational Diabetes Program, Internal Medicine I, Heidelberg University Hospital, Heidelberg, Germany
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Stephan Herzig
6Joint Heidelberg-IDC Translational Diabetes Program, Internal Medicine I, Heidelberg University Hospital, Heidelberg, Germany
7Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany
8Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany
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Johanna Zemva
1Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
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  • ORCID record for Johanna Zemva
  • For correspondence: johanna.zemva@med.uni-heidelberg.de
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Article Information

doi 
https://doi.org/10.1101/2021.11.30.470545
History 
  • November 30, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Ruben Bulkescher1,
  2. Thomas Fleming1,2,
  3. Claus Rodemer1,
  4. Rebekka Medert3,
  5. Marc Freichel3,
  6. Matthias Mayer4,5,
  7. Julia Szendroedi1,2,6,
  8. Stephan Herzig6,7,8 and
  9. Johanna Zemva1,*
  1. 1Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany
  2. 2German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany
  3. 3Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
  4. 4Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany
  5. 5DKFZ-ZMBH Alliance, Heidelberg, Germany
  6. 6Joint Heidelberg-IDC Translational Diabetes Program, Internal Medicine I, Heidelberg University Hospital, Heidelberg, Germany
  7. 7Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, Neuherberg, Germany
  8. 8Chair Molecular Metabolic Control, Technical University Munich, Munich, Germany
  1. ↵*Corresponding author. E-Mail: johanna.zemva{at}med.uni-heidelberg.de (JZ)
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Induction of mitochondrial heat shock proteins and mitochondrial biogenesis in endothelial cells upon acute methylglyoxal stress: Evidence for hormetic autofeedback
Ruben Bulkescher, Thomas Fleming, Claus Rodemer, Rebekka Medert, Marc Freichel, Matthias Mayer, Julia Szendroedi, Stephan Herzig, Johanna Zemva
bioRxiv 2021.11.30.470545; doi: https://doi.org/10.1101/2021.11.30.470545
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Induction of mitochondrial heat shock proteins and mitochondrial biogenesis in endothelial cells upon acute methylglyoxal stress: Evidence for hormetic autofeedback
Ruben Bulkescher, Thomas Fleming, Claus Rodemer, Rebekka Medert, Marc Freichel, Matthias Mayer, Julia Szendroedi, Stephan Herzig, Johanna Zemva
bioRxiv 2021.11.30.470545; doi: https://doi.org/10.1101/2021.11.30.470545

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