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Oligodendrocytes are a lifelong source of nuclear and ribosomal material for neurons in the mouse brain

Florian Mayrhofer, Angela M. Hanson, Carmen Falcone, Yang K. Xiang, Manuel F. Navedo, Wenbin Deng, View ORCID ProfileOlga Chechneva
doi: https://doi.org/10.1101/2021.11.30.470658
Florian Mayrhofer
1IPRM, Shriners Hospital for Children, University of California Davis, School of Medicine, Sacramento, CA 95817
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  • For correspondence: ochechneva@ucdavis.edu fmayrhofer@gmail.com
Angela M. Hanson
1IPRM, Shriners Hospital for Children, University of California Davis, School of Medicine, Sacramento, CA 95817
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Carmen Falcone
1IPRM, Shriners Hospital for Children, University of California Davis, School of Medicine, Sacramento, CA 95817
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Yang K. Xiang
3Department of Pharmacology, University of California Davis, Davis, CA 95616
4Northern California Health Care System, Mather, CA
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Manuel F. Navedo
3Department of Pharmacology, University of California Davis, Davis, CA 95616
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Wenbin Deng
1IPRM, Shriners Hospital for Children, University of California Davis, School of Medicine, Sacramento, CA 95817
2Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA 95817
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Olga Chechneva
1IPRM, Shriners Hospital for Children, University of California Davis, School of Medicine, Sacramento, CA 95817
2Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA 95817
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  • ORCID record for Olga Chechneva
  • For correspondence: ochechneva@ucdavis.edu fmayrhofer@gmail.com
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Abstract

Nuclear and ribosomal components define cell identity and function by regulating chromatin dynamics, gene expression, and protein turnover. Here we report that in the mouse central nervous system (CNS) under normal conditions, neurons accumulate nuclear and ribosomal material of oligodendrocyte (OL) origin. We show that neuronal accumulation of OL-derived nuclear and ribosomal material is brain area-specific, and in the cortex and hippocampal dentate gyrus gradually propagates during postnatal brain maturation. We further demonstrate that OL-to-neuron material transfer persists throughout adulthood and responds to neuroinflammation. We found that satellite OL of the gray matter form internuclear contacts with receiving neurons in the mouse brain. Similar close internuclear associations between satellite OL and neurons are present in the adult human cortex. Our findings provide the first evidence of wide-spread dynamic and selective OL-to-neuron nuclear and ribosomal material transfer in the mouse CNS and indicate that satellite OL serve as powerful mediators of neuronal function. Equivalent processes may occur in the human CNS and cause neurological disorders when dysregulated.

One Sentence Summary Neurons receive OL-derived nuclear and ribosomal material

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted December 01, 2021.
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Oligodendrocytes are a lifelong source of nuclear and ribosomal material for neurons in the mouse brain
Florian Mayrhofer, Angela M. Hanson, Carmen Falcone, Yang K. Xiang, Manuel F. Navedo, Wenbin Deng, Olga Chechneva
bioRxiv 2021.11.30.470658; doi: https://doi.org/10.1101/2021.11.30.470658
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Oligodendrocytes are a lifelong source of nuclear and ribosomal material for neurons in the mouse brain
Florian Mayrhofer, Angela M. Hanson, Carmen Falcone, Yang K. Xiang, Manuel F. Navedo, Wenbin Deng, Olga Chechneva
bioRxiv 2021.11.30.470658; doi: https://doi.org/10.1101/2021.11.30.470658

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