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A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state

Beverly Setzer, Nina E. Fultz, Daniel E. P. Gomez, Stephanie D. Williams, Giorgio Bonmassar, Jonathan R. Polimeni, Laura D. Lewis
doi: https://doi.org/10.1101/2021.12.01.470627
Beverly Setzer
1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
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Nina E. Fultz
1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
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Daniel E. P. Gomez
1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
3Department of Radiology, Harvard Medical School. Boston, MA 02115, USA
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Stephanie D. Williams
1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
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Giorgio Bonmassar
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
3Department of Radiology, Harvard Medical School. Boston, MA 02115, USA
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Jonathan R. Polimeni
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
3Department of Radiology, Harvard Medical School. Boston, MA 02115, USA
4Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
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Laura D. Lewis
1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
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  • For correspondence: ldlewis@bu.edu
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ABSTRACT

The moment of awakening from sleep reflects a profound transformation in neural activity and behavior. The thalamus is a key controller of arousal state, but whether its diverse nuclei exhibit coordinated or distinct activity at transitions in behavioral arousal state is not known. Using fast fMRI at ultra-high field (7 Tesla), we measured sub-second activity across thalamocortical networks and within nine thalamic nuclei to delineate these dynamics during spontaneous transitions in behavioral arousal state. We discovered a stereotyped sequence of activity across thalamic nuclei that preceded behavioral arousal after a period of inactivity, followed by widespread cortical deactivation. These thalamic dynamics were linked to whether participants remained awake or fell back asleep, with unified thalamic activation reflecting subsequent maintenance of awake behavior. These results provide an outline of the complex interactions across thalamocortical circuits that orchestrate arousal state transitions, and additionally, demonstrate that fast fMRI can resolve sub-second subcortical dynamics in the human brain.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 02, 2021.
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A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state
Beverly Setzer, Nina E. Fultz, Daniel E. P. Gomez, Stephanie D. Williams, Giorgio Bonmassar, Jonathan R. Polimeni, Laura D. Lewis
bioRxiv 2021.12.01.470627; doi: https://doi.org/10.1101/2021.12.01.470627
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A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state
Beverly Setzer, Nina E. Fultz, Daniel E. P. Gomez, Stephanie D. Williams, Giorgio Bonmassar, Jonathan R. Polimeni, Laura D. Lewis
bioRxiv 2021.12.01.470627; doi: https://doi.org/10.1101/2021.12.01.470627

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