Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

CaveCrawler: An interactive analysis suite for cavefish bioinformatics

Annabel Perry, Suzanne E. McGaugh, Alex C. Keene, Heath Blackmon
doi: https://doi.org/10.1101/2021.12.01.470856
Annabel Perry
1Department of Biology, Texas A&M University, College Station, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Suzanne E. McGaugh
2Ecology, Evolution, and Behavior, University of Minnesota, Saint Paul, Minnesota, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alex C. Keene
1Department of Biology, Texas A&M University, College Station, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: hblackmon@bio.tamu.edu akeene@bio.tamu.edu
Heath Blackmon
1Department of Biology, Texas A&M University, College Station, TX
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: hblackmon@bio.tamu.edu akeene@bio.tamu.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

The growing use of genomics data in diverse animal models provides the basis for identifying genomic and transcriptional differences across species and contexts. Databases containing genomic and functional data have played critical roles in the development of numerous genetic models but are lacking for most emerging models of evolution. There is a rapidly expanding use of genomic, transcriptional, and functional genetic approaches to study diverse traits of the Mexican tetra, Astyanax mexicanus. This species exists as two morphs, eyed surface populations and at least 30 blind cave populations, providing a system to study convergent evolution. We have generated a web-based analysis suite that integrates datasets from different studies to identify how gene transcription and genetic markers of selection differ between populations and across experimental contexts. Results can be processed with other analysis platforms including Gene Ontology (GO) to enable biological inference from cross-study patterns and identify future avenues of research. Furthermore, the framework that we have built A. mexicanus can readily applied to other emerging model systems.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Back to top
PreviousNext
Posted December 03, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
CaveCrawler: An interactive analysis suite for cavefish bioinformatics
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
CaveCrawler: An interactive analysis suite for cavefish bioinformatics
Annabel Perry, Suzanne E. McGaugh, Alex C. Keene, Heath Blackmon
bioRxiv 2021.12.01.470856; doi: https://doi.org/10.1101/2021.12.01.470856
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
CaveCrawler: An interactive analysis suite for cavefish bioinformatics
Annabel Perry, Suzanne E. McGaugh, Alex C. Keene, Heath Blackmon
bioRxiv 2021.12.01.470856; doi: https://doi.org/10.1101/2021.12.01.470856

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Bioinformatics
Subject Areas
All Articles
  • Animal Behavior and Cognition (4112)
  • Biochemistry (8814)
  • Bioengineering (6518)
  • Bioinformatics (23459)
  • Biophysics (11789)
  • Cancer Biology (9206)
  • Cell Biology (13321)
  • Clinical Trials (138)
  • Developmental Biology (7435)
  • Ecology (11409)
  • Epidemiology (2066)
  • Evolutionary Biology (15147)
  • Genetics (10436)
  • Genomics (14042)
  • Immunology (9170)
  • Microbiology (22152)
  • Molecular Biology (8811)
  • Neuroscience (47564)
  • Paleontology (350)
  • Pathology (1428)
  • Pharmacology and Toxicology (2491)
  • Physiology (3730)
  • Plant Biology (8079)
  • Scientific Communication and Education (1437)
  • Synthetic Biology (2220)
  • Systems Biology (6037)
  • Zoology (1253)