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CTP synthase does not form cytoophidia in Drosophila interfollicular stalks

Zheng Wu, View ORCID ProfileJi-Long Liu
doi: https://doi.org/10.1101/2021.12.02.470862
Zheng Wu
1School of Life Science and Technology, ShanghaiTech University, 230 Haike Road, 201210, Shanghai, China
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Ji-Long Liu
1School of Life Science and Technology, ShanghaiTech University, 230 Haike Road, 201210, Shanghai, China
2Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3PT, United Kingdom
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  • ORCID record for Ji-Long Liu
  • For correspondence: liujl3@shanghaitech.edu.cn jilong.liu@dpag.ox.ac.uk
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ABSTRACT

CTP synthase (CTPS) catalyzes the final step of de novo synthesis of the nucleotide CTP. In 2010, CTPS has been found to form filamentous structures termed cytoophidia in Drosophila follicle cells and germline cells. Subsequently, cytoophidia have been reported in many species across three domains of life: bacteria, eukaryotes and archaea. Forming cytoophidia appears to be a highly conserved and ancient property of CTPS. To our surprise, here we find that polar cells and stalk cells, two specialized types of cells composing Drosophila interfollicular stalks, do not possess obvious cytoophidia. Moreover, we show that Myc level is low in these two types of cells, supporting the idea that Myc regulates cytoophidium assembly. Treatment with a glutamine analog, 6-diazo-5-oxo-l-norleucine (DON), increases cytoophidium assembly in main follicle cells, but not in polar cells or stalk cells. Our findings provide an interesting paradigm for the in vivo study of cytoophidium assembly and disassembly among different populations of follicle cells.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted December 03, 2021.
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CTP synthase does not form cytoophidia in Drosophila interfollicular stalks
Zheng Wu, Ji-Long Liu
bioRxiv 2021.12.02.470862; doi: https://doi.org/10.1101/2021.12.02.470862
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CTP synthase does not form cytoophidia in Drosophila interfollicular stalks
Zheng Wu, Ji-Long Liu
bioRxiv 2021.12.02.470862; doi: https://doi.org/10.1101/2021.12.02.470862

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