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A Substrate-triggered µ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
View ORCID ProfileMolly J. McBride, View ORCID ProfileMrutyunjay A. Nair, View ORCID ProfileDebangsu Sil, View ORCID ProfileJeffrey W. Slater, View ORCID ProfileMonica Neugebauer, View ORCID ProfileMichelle C. Y. Chang, View ORCID ProfileAmie K. Boal, View ORCID ProfileCarsten Krebs, View ORCID ProfileJ. Martin Bollinger Jr.
doi: https://doi.org/10.1101/2021.12.02.471016
Molly J. McBride
†Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
Mrutyunjay A. Nair
†Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
Debangsu Sil
†Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
Jeffrey W. Slater
†Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
Monica Neugebauer
§Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA
#Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, United States
Michelle C. Y. Chang
§Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA
‖Departments of Chemistry and of Molecular and Cell Biology, University of California, Berkeley, and Lawrence Berkeley National Laboratory, Berkeley, CA, USA
Amie K. Boal
†Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
┴Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
Carsten Krebs
†Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
┴Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
J. Martin Bollinger Jr.
†Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
┴Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
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Posted January 05, 2022.
A Substrate-triggered µ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, Jeffrey W. Slater, Monica Neugebauer, Michelle C. Y. Chang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger Jr.
bioRxiv 2021.12.02.471016; doi: https://doi.org/10.1101/2021.12.02.471016
A Substrate-triggered µ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
Molly J. McBride, Mrutyunjay A. Nair, Debangsu Sil, Jeffrey W. Slater, Monica Neugebauer, Michelle C. Y. Chang, Amie K. Boal, Carsten Krebs, J. Martin Bollinger Jr.
bioRxiv 2021.12.02.471016; doi: https://doi.org/10.1101/2021.12.02.471016
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