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Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiří Zahradník, Piyada Supasa, Chang Liu, Helen M.E. Duyvesteyn, Helen M. Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite, Suman Khan, Ori Avinoam, Mohammad Bahar, Donal Skelly, Sandra Adele, Sile Ann Johnson, Ali Amini, Thomas Ritter, Chris Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nikki Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K Aley, View ORCID ProfileMerryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, View ORCID ProfilePaola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Vicky Baillie, Natali Serafin, Zanele Ditse, Kelly Da Silva, Shabir Madhi, Marta C Nunes, Tariq Malik, View ORCID ProfilePeter JM Openshaw, View ORCID ProfileJ Kenneth Baillie, View ORCID ProfileMalcolm G Semple, View ORCID ProfileAlain R Townsend, Kuan-Ying A. Huang, View ORCID ProfileTiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Bede Constantinides, Hermione Webster, Derrick Crook, Andrew J Pollard, Teresa Lambe, OPTIC consortium, ISARIC4C consortium, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Gideon Schreiber, View ORCID ProfileDavid I. Stuart, Gavin R Screaton
doi: https://doi.org/10.1101/2021.12.03.471045
Wanwisa Dejnirattisai
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Jiandong Huo
2Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
Daming Zhou
2Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
3Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
Jiří Zahradník
4Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
Piyada Supasa
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Chang Liu
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
3Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
Helen M.E. Duyvesteyn
2Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
Helen M. Ginn
5Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK
Alexander J. Mentzer
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Aekkachai Tuekprakhon
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Rungtiwa Nutalai
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Beibei Wang
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Aiste Dijokaite
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Suman Khan
4Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
Ori Avinoam
4Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
Mohammad Bahar
2Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
Donal Skelly
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
7Peter Medawar Building for Pathogen Research, Oxford, UK
8Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Sandra Adele
7Peter Medawar Building for Pathogen Research, Oxford, UK
Sile Ann Johnson
7Peter Medawar Building for Pathogen Research, Oxford, UK
Ali Amini
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
9Translational Gastroenterology Unit, University of Oxford, Oxford, UK
7Peter Medawar Building for Pathogen Research, Oxford, UK
Thomas Ritter
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Chris Mason
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
Christina Dold
10NIHR Oxford Biomedical Research Centre, Oxford, UK
11Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
Daniel Pan
12Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust,
13Department of Respiratory Sciences, University of Leicester
Sara Assadi
12Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust,
Adam Bellass
12Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust,
Nikki Omo-Dare
12Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust,
David Koeckerling
14Medical Sciences Division, University of Oxford
Amy Flaxman
15Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Daniel Jenkin
15Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Parvinder K Aley
11Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
Merryn Voysey
11Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
Sue Ann Costa Clemens
16Institute of Global Health, University of Siena, Siena, Brazil; Department of Paediatrics, University of Oxford, Oxford, UK
Felipe Gomes Naveca
17Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil
Valdinete Nascimento
17Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil
Fernanda Nascimento
17Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil
Cristiano Fernandes da Costa
18Fundação de Vigilância em Saúde do Amazonas, Manaus, Amazonas, Brazil
Paola Cristina Resende
19Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil
Alex Pauvolid-Correa
19Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil
20Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States
Marilda M. Siqueira
19Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil
Vicky Baillie
21South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
22Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Natali Serafin
21South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
22Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Zanele Ditse
21South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
22Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Kelly Da Silva
21South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
22Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Shabir Madhi
21South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
22Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Marta C Nunes
21South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
22Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Tariq Malik
23National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK
Peter JM Openshaw
24National Heart & Lung Institute, Imperial College London
J Kenneth Baillie
25Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, UK
Malcolm G Semple
26NIHR Health Protection Research Unit, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
Alain R Townsend
3Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
27MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK
Kuan-Ying A. Huang
28Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan
Tiong Kit Tan
27MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK
Miles W. Carroll
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
29National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK
Paul Klenerman
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
7Peter Medawar Building for Pathogen Research, Oxford, UK
9Translational Gastroenterology Unit, University of Oxford, Oxford, UK
10NIHR Oxford Biomedical Research Centre, Oxford, UK
Eleanor Barnes
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
7Peter Medawar Building for Pathogen Research, Oxford, UK
9Translational Gastroenterology Unit, University of Oxford, Oxford, UK
10NIHR Oxford Biomedical Research Centre, Oxford, UK
Susanna J. Dunachie
6Oxford University Hospitals NHS Foundation Trust, Oxford, UK
7Peter Medawar Building for Pathogen Research, Oxford, UK
30Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
31Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, Department of Medicine, University of Oxford, Oxford, UK
Bede Constantinides
32Nuffield Department of Medicine, University of Oxford, Oxford, UK
Hermione Webster
32Nuffield Department of Medicine, University of Oxford, Oxford, UK
Derrick Crook
32Nuffield Department of Medicine, University of Oxford, Oxford, UK
Andrew J Pollard
10NIHR Oxford Biomedical Research Centre, Oxford, UK
11Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
Teresa Lambe
3Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
11Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
Neil G. Paterson
5Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK
Mark A. Williams
5Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK
David R. Hall
5Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK
Elizabeth E. Fry
2Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
Juthathip Mongkolsapaya
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
3Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
33Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
Jingshan Ren
2Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
Gideon Schreiber
4Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel
David I. Stuart
2Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
3Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
5Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK
34Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK
Gavin R Screaton
1Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
3Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
Article usage
Posted December 22, 2021.
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiří Zahradník, Piyada Supasa, Chang Liu, Helen M.E. Duyvesteyn, Helen M. Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite, Suman Khan, Ori Avinoam, Mohammad Bahar, Donal Skelly, Sandra Adele, Sile Ann Johnson, Ali Amini, Thomas Ritter, Chris Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nikki Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K Aley, Merryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Vicky Baillie, Natali Serafin, Zanele Ditse, Kelly Da Silva, Shabir Madhi, Marta C Nunes, Tariq Malik, Peter JM Openshaw, J Kenneth Baillie, Malcolm G Semple, Alain R Townsend, Kuan-Ying A. Huang, Tiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Bede Constantinides, Hermione Webster, Derrick Crook, Andrew J Pollard, Teresa Lambe, OPTIC consortium, ISARIC4C consortium, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Gideon Schreiber, David I. Stuart, Gavin R Screaton
bioRxiv 2021.12.03.471045; doi: https://doi.org/10.1101/2021.12.03.471045
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
Wanwisa Dejnirattisai, Jiandong Huo, Daming Zhou, Jiří Zahradník, Piyada Supasa, Chang Liu, Helen M.E. Duyvesteyn, Helen M. Ginn, Alexander J. Mentzer, Aekkachai Tuekprakhon, Rungtiwa Nutalai, Beibei Wang, Aiste Dijokaite, Suman Khan, Ori Avinoam, Mohammad Bahar, Donal Skelly, Sandra Adele, Sile Ann Johnson, Ali Amini, Thomas Ritter, Chris Mason, Christina Dold, Daniel Pan, Sara Assadi, Adam Bellass, Nikki Omo-Dare, David Koeckerling, Amy Flaxman, Daniel Jenkin, Parvinder K Aley, Merryn Voysey, Sue Ann Costa Clemens, Felipe Gomes Naveca, Valdinete Nascimento, Fernanda Nascimento, Cristiano Fernandes da Costa, Paola Cristina Resende, Alex Pauvolid-Correa, Marilda M. Siqueira, Vicky Baillie, Natali Serafin, Zanele Ditse, Kelly Da Silva, Shabir Madhi, Marta C Nunes, Tariq Malik, Peter JM Openshaw, J Kenneth Baillie, Malcolm G Semple, Alain R Townsend, Kuan-Ying A. Huang, Tiong Kit Tan, Miles W. Carroll, Paul Klenerman, Eleanor Barnes, Susanna J. Dunachie, Bede Constantinides, Hermione Webster, Derrick Crook, Andrew J Pollard, Teresa Lambe, OPTIC consortium, ISARIC4C consortium, Neil G. Paterson, Mark A. Williams, David R. Hall, Elizabeth E. Fry, Juthathip Mongkolsapaya, Jingshan Ren, Gideon Schreiber, David I. Stuart, Gavin R Screaton
bioRxiv 2021.12.03.471045; doi: https://doi.org/10.1101/2021.12.03.471045
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