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Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo
View ORCID ProfileMichael Schubert, Christy Hong, Laura J. Jilderda, Marta Requesens Rueda, Andréa E. Tijhuis, Judith E. Simon, Petra L. Bakker, Jon L. Cooper, Aristi Damaskou, René Wardenaar, Bjorn Bakker, Sahil Gupta, Anouk van den Brink, Lorena Andrade Ruiz, Miriam H. Koster, Sameh A. Youssef, Danielle Luinenburg, Alex Strong, Thomas Engleitner, Hannes Ponstingl, Gerald de Haan, Alain de Bruin, Roland Rad, Hans W. Nijman, René H. Medema, Marcel A.T.M. van Vugt, Marco de Bruyn, Diana C.J. Spierings, Maria Colomé-Tatché, George S. Vassiliou, View ORCID ProfileFloris Foijer
doi: https://doi.org/10.1101/2021.12.03.471107
Michael Schubert
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
2Division of Cell Biology and Cancer Genomics Center, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands
3Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
Christy Hong
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Laura J. Jilderda
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Marta Requesens Rueda
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
4Department of Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Andréa E. Tijhuis
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Judith E. Simon
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Petra L. Bakker
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Jon L. Cooper
5Wellcome–Medical Research Council (MRC) Cambridge Stem Cell Institute, Cambridge, United Kingdom
6Department of Haematology, Cambridge University Hospitals National Health Service (NHS) Trust, Cambridge, United Kingdom
7Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
Aristi Damaskou
5Wellcome–Medical Research Council (MRC) Cambridge Stem Cell Institute, Cambridge, United Kingdom
6Department of Haematology, Cambridge University Hospitals National Health Service (NHS) Trust, Cambridge, United Kingdom
René Wardenaar
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Bjorn Bakker
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Sahil Gupta
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Anouk van den Brink
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Lorena Andrade Ruiz
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Miriam H. Koster
8Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Sameh A. Youssef
9Dutch Molecular Pathology Center, Department of Biomolecular Health Sciences, Utrecht University, Faculty of Veterinary Medicine, 3584 CL, Utrecht, the Netherlands
Danielle Luinenburg
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Alex Strong
7Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
Thomas Engleitner
10Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany
Hannes Ponstingl
7Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
Gerald de Haan
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Alain de Bruin
8Department of Pediatrics, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
9Dutch Molecular Pathology Center, Department of Biomolecular Health Sciences, Utrecht University, Faculty of Veterinary Medicine, 3584 CL, Utrecht, the Netherlands
Roland Rad
10Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany
Hans W. Nijman
4Department of Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
René H. Medema
2Division of Cell Biology and Cancer Genomics Center, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands
Marcel A.T.M. van Vugt
11Department of Medical Oncology, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Marco de Bruyn
4Department of Obstetrics and Gynaecology, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Diana C.J. Spierings
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Maria Colomé-Tatché
3Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
George S. Vassiliou
5Wellcome–Medical Research Council (MRC) Cambridge Stem Cell Institute, Cambridge, United Kingdom
6Department of Haematology, Cambridge University Hospitals National Health Service (NHS) Trust, Cambridge, United Kingdom
7Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
Floris Foijer
1European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV, Groningen, the Netherlands
Posted December 04, 2021.
Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo
Michael Schubert, Christy Hong, Laura J. Jilderda, Marta Requesens Rueda, Andréa E. Tijhuis, Judith E. Simon, Petra L. Bakker, Jon L. Cooper, Aristi Damaskou, René Wardenaar, Bjorn Bakker, Sahil Gupta, Anouk van den Brink, Lorena Andrade Ruiz, Miriam H. Koster, Sameh A. Youssef, Danielle Luinenburg, Alex Strong, Thomas Engleitner, Hannes Ponstingl, Gerald de Haan, Alain de Bruin, Roland Rad, Hans W. Nijman, René H. Medema, Marcel A.T.M. van Vugt, Marco de Bruyn, Diana C.J. Spierings, Maria Colomé-Tatché, George S. Vassiliou, Floris Foijer
bioRxiv 2021.12.03.471107; doi: https://doi.org/10.1101/2021.12.03.471107
Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo
Michael Schubert, Christy Hong, Laura J. Jilderda, Marta Requesens Rueda, Andréa E. Tijhuis, Judith E. Simon, Petra L. Bakker, Jon L. Cooper, Aristi Damaskou, René Wardenaar, Bjorn Bakker, Sahil Gupta, Anouk van den Brink, Lorena Andrade Ruiz, Miriam H. Koster, Sameh A. Youssef, Danielle Luinenburg, Alex Strong, Thomas Engleitner, Hannes Ponstingl, Gerald de Haan, Alain de Bruin, Roland Rad, Hans W. Nijman, René H. Medema, Marcel A.T.M. van Vugt, Marco de Bruyn, Diana C.J. Spierings, Maria Colomé-Tatché, George S. Vassiliou, Floris Foijer
bioRxiv 2021.12.03.471107; doi: https://doi.org/10.1101/2021.12.03.471107
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