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Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s Disease Through Complement-Dependent Mechanisms
D.K. Wilton, K. Mastro, M.D. Heller, F.W. Gergits, C R. Willing, A. Frouin, A. Daggett, X. Gu, A.Y. Kim, R. Faull, S. Jayadev, T Yednock, X.W. Yang, View ORCID ProfileB. Stevens
doi: https://doi.org/10.1101/2021.12.03.471180
D.K. Wilton
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
K. Mastro
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
M.D. Heller
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
F.W. Gergits
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
C R. Willing
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
A. Frouin
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
A. Daggett
2Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
X. Gu
2Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
A.Y. Kim
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
R. Faull
3The University of Auckland, M&HS Building 503, Grafton, Auckland, New Zealand
S. Jayadev
4Department of Neurology University of Washington Seattle Washington
5Division Medical Genetics Department of Medicine University of Washington Seattle Washington
T Yednock
6Annexon Biosciences, South San Francisco, CA 94080, USA
X.W. Yang
2Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
B. Stevens
1Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, US
7Stanley Center, Broad Institute, Cambridge, Massachusetts, 02142, USA
8Howard Hughes Medical Institute, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
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Posted December 04, 2021.
Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s Disease Through Complement-Dependent Mechanisms
D.K. Wilton, K. Mastro, M.D. Heller, F.W. Gergits, C R. Willing, A. Frouin, A. Daggett, X. Gu, A.Y. Kim, R. Faull, S. Jayadev, T Yednock, X.W. Yang, B. Stevens
bioRxiv 2021.12.03.471180; doi: https://doi.org/10.1101/2021.12.03.471180
Microglia Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s Disease Through Complement-Dependent Mechanisms
D.K. Wilton, K. Mastro, M.D. Heller, F.W. Gergits, C R. Willing, A. Frouin, A. Daggett, X. Gu, A.Y. Kim, R. Faull, S. Jayadev, T Yednock, X.W. Yang, B. Stevens
bioRxiv 2021.12.03.471180; doi: https://doi.org/10.1101/2021.12.03.471180
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