Article Information
History
- December 6, 2021.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Lan Wang1,2,#,
- Morgane Boone1,2,#,
- Rosalie E Lawrence1,2,
- Adam Frost2,3,
- Peter Walter1,2,* and
- Michael Schoof1,2,*
- 1Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
- 2Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA
- 3Chan Zuckerberg Biohub, San Francisco, CA, USA
- ↵*Correspondence: peter{at}walterlab.ucsf.edu; michael{at}walterlab.ucsf.edu
↵# These authors contributed equally
Posted December 06, 2021.
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation
