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Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates

Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
doi: https://doi.org/10.1101/2021.12.05.471256
Sean Chia
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Z. Faidon Brotzakis
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Robert I. Horne
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Andrea Possenti
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Benedetta Mannini
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Rodrigo Cataldi
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Magdalena Nowinska
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Roxine Staats
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Sara Linse
2Department of Biochemistry & Structural Biology, Center for Molecular Protein Science, Lund University, 221 00 Lund, Sweden
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Tuomas P. J. Knowles
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
3Department of Physics, Cavendish Laboratory, Cambridge CB3 0HE, UK
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Johnny Habchi
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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Michele Vendruscolo
1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
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  • For correspondence: mv245@cam.ac.uk
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Article Information

doi 
https://doi.org/10.1101/2021.12.05.471256
History 
  • December 5, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Sean Chia1,
  2. Z. Faidon Brotzakis1,
  3. Robert I. Horne1,
  4. Andrea Possenti1,
  5. Benedetta Mannini1,
  6. Rodrigo Cataldi1,
  7. Magdalena Nowinska1,
  8. Roxine Staats1,
  9. Sara Linse2,
  10. Tuomas P. J. Knowles1,3,
  11. Johnny Habchi1 and
  12. Michele Vendruscolo1,*
  1. 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK
  2. 2Department of Biochemistry & Structural Biology, Center for Molecular Protein Science, Lund University, 221 00 Lund, Sweden
  3. 3Department of Physics, Cavendish Laboratory, Cambridge CB3 0HE, UK
  1. ↵* Corresponding author; email: mv245{at}cam.ac.uk
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Posted December 05, 2021.
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Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
bioRxiv 2021.12.05.471256; doi: https://doi.org/10.1101/2021.12.05.471256
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Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
bioRxiv 2021.12.05.471256; doi: https://doi.org/10.1101/2021.12.05.471256

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